Psychosis risk reduced for 80 weeks by just 12 weeks of Omega-3 – RCT

Predictors of longer-term outcome in the Vienna omega-3 high-risk study

Schitophrenia Research, DOI: http://dx.doi.org/10.1016/j.schres.2017.08.010

Nilufar Mossahebr, Nilufar Mossaheb, Nilufar Mossaheb, Miriam R. Schäfer, Miriam R. Schäfer, Monika Schlögelhofer Monika Schlögelhofer, Claudia M. Klier, Claudia M. Klier, Stefan . . .

* Omega-3 reduces many psychiatric disorders – 2 reviews 2016 * Schizophrenia treated by 6 months of Omega-3 – RCT Nov 2015 * Omega-3 reduced aggressive incidents in prisoners by 30 percent – RCT June 2018 * Violent schizophrenia patients treated by 3 months of Omega-3 – RCT Aug 2017 * Omega-3 for just 3 months greatly reduced psychosis for 80 months – RCT Aug 2015 * different publication, different authors, same data Overview Schizophrenia and Vitamin D contains the following summary {include} Items in BOTH of the categories Cognition and Omega-3 {category}

Longer-term data on ω-3 polyunsaturated fatty acids (PUFA) for prevention of psychosis in (ultra high risk) UHR individuals have initially shown promising results.

This analysis aimed to assess clinical predictors of longer-term outcome in UHR individuals treated with ω-3 PUFAs versus placebo.

Data derived from an RCT in 81 UHR individuals treated with ω-3 PUFAs versus placebo for 12 weeks and follow-up assessment after a median of 6.7 years.

Baseline GAF, baseline PANSS global score, pre-to-post-intervention change in EPA (Eicosapentaenoic acid) level were significant predictors of transition to psychosis, PANSS negative score and baseline MADRS reached trend-levels. In the final multivariate Cox regression analysis change in EPA levels remained the only significant predictor.

Taking into account all other significant predictors, changes in EPA levels were found to be the single most significant predictor for transition to psychosis in a longer term observation of UHR individuals.

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