Preterm birth 4X more likely if very low Vitamin D (Chinese)

Created February 2018

Influent factors of gestational vitamin D deficiency and its relation to an increased risk of preterm delivery in Chinese population.

Sci Rep. 2018 Feb 26;8(1):3608. doi: 10.1038/s41598-018-21944-3.

Chen YH1,2,3, Fu L1, Hao JH1,3, Wang H1, Zhang C1, Tao FB1,3, Xu DX4,5.

1. Gestational vitamin D status | | | | | | --- | --- | --- | --- | | | Sufficiency | Insufficiency | Deficiency | | Adjusted Preterm Risk | 1.00 | 2.1 | 4.0 | | Adjusted Early Preterm Risk | 1.00 | 0.54 | 3.0 | --- 1. See also VitaminDWiki * Preterm birth rate reduced 57 percent by Vitamin D – Nov 2015 intervention * Preterm birth rate reduced by 43 percent with adequate Vitamin D supplementation – meta-analysis Feb 2017 * Preterm birth far more likely if previous miscarriage and poor Vitamin D receptor – Aug 2017 * Preterm births strongly related to Vitamin D, Vitamin D Receptor, Iodine, Omega-3, etc * Preterm birth rates increased in 15 European countries – Oct 2013 * Vitamin D intervention reduces preterm births and low birth weight by 60 percent – Cochrane Reviews – Nov 2017 * Preterm birth cost for employers approximately 50,000 dollars – Oct 2017 * Premature birth and infant mortality worse if dark skin (low vitamin D) - 2015 * Low Vitamin D – 2X more likely to have premie AND mother later to have heart problems – Feb 2015 Healthy pregnancies need lots of vitamin D has the following summary {include} Preterm births are VERY costly – Feb 2017 contains this cost-analysis {include}

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Gestational vitamin D deficiency (VDD) has been linked with adverse pregnant outcomes. To investigate influent factors of gestational VDD and its relation to the incidence of preterm delivery, total 3598 eligible mother-and-singleton-offspring pairs were recruited. For serum 25(OH)D concentration, 941 pregnant women were sufficient, 1260 insufficient, and 1397 deficient. Further analysis showed that VDD was more prevalent in winter than in other seasons. Underweight but not overweight was a risk factor for gestational VDD. Multivitamin use reduced risk of gestational VDD. Interestingly, 8.23% delivered preterm infants among subjects with VDD (adjusted RR: 4.02; 95% CI: 2.33, 6.92) and 3.81% among subjects with gestational vitamin D insufficiency (VDI) (adjusted RR: 2.07; 95% CI: 1.16, 3.71). Moreover, 2.59% delivered early preterm infants among subjects with VDD (adjusted RR: 2.97; 95% CI: 1.41, 6.24) and 0.49% among subjects with VDI (adjusted RR: 0.54; 95% CI: 0.19, 1.51). The incidence of late preterm delivery was 5.64% among subjects with VDD (adjusted RR: 3.90; 95% CI: 2.26, 6.72) and 3.32% among subjects with VDI (adjusted RR: 2.09; 95% CI: 1.17, 3.74). In conclusion, pre-pregnancy BMI, seasonality and multivitamin use are influent factors of gestational vitamin D status. Gestational VDD is associated with an increased risk of preterm delivery in Chinese population.

PMID: 29483547 DOI: 10.1038/s41598-018-21944-3

Tags: Pregnancy