Poor sleep associated with 2X increase risk of Metabolic problems (both low Vitamin D)

Created June 2019

Cross-sectional and Prospective Associations of Actigraphy-Assessed Sleep Regularity With Metabolic Abnormalities: The Multi-Ethnic Study of Atherosclerosis

Diabetes Care 2019 May; https://doi.org/10.2337/dc19-0596

Tianyi Huang, Susan Redline

This study found associations Possible relationships include * Low Vitamin D ==> Poor Sleep ==> Metabolic problems * Poor Sleep ==> Low Vitamin D ==> Metabolic Problems But, more important, Add Vitamin D ==> improves sleep AND Add Vitamin D ==> Reduces Metabolic problems Items in both categories Metabolic Syndrome and Intervention: {category} Items in both categories Sleep and Intervention: {category} See other studies in VitaminDWiki * Vitamin D deficiency increases risk of Metabolic Syndrome – 1998 * Metabolic Syndrome risk increases about 70 percent if poor Vitamin D Receptor * Poor sleep 1.5 X more likely if less than 20 ng of Vitamin D – meta-analysis Oct 2018 * Shift workers have low vitamin D, poorer sleep, and are more depressed – March 2019 * Sleep may be regulated by Vitamin D via two pathways – Nov 2018

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OBJECTIVE To cross-sectionally and prospectively investigate the association between irregular sleep patterns, a potential marker for circadian disruption, and metabolic abnormalities.

RESEARCH DESIGN AND METHODS In the Multi-Ethnic Study of Atherosclerosis, participants completed 7-day actigraphy at exam 5 (2010–2013) and were prospectively followed throughout exam 6 (2016 to 2017). Sleep regularity was quantified by the 7-day SD of actigraphy-assessed sleep duration and sleep onset timing. Metabolic abnormalities were defined by 1) the National Cholesterol Education Program Adult Treatment Panel III criteria and 2) a data-driven clustering of metabolic factors.

RESULTS In the exam 5 cross-sectional analysis adjusted for sociodemographic and lifestyle factors (n = 2,003), every 1-h increase in the sleep duration SD was associated with 27% (95% CI 1.10, 1.47) higher odds of metabolic syndrome, and every 1-h increase in the sleep timing SD was associated with 23% (95% CI 1.06, 1.42) higher odds. The associations remained significant, with additional adjustment for sleep-related factors including sleep duration. In the prospective analysis (n = 970), the corresponding fully adjusted odds ratio (OR) (95% CI) was 1.27 (0.97, 1.65) for sleep duration and 1.36 (1.03, 1.80) for sleep timing. Compared with the cluster of few metabolic changes, every 1-h increase in sleep variability was associated with almost doubled odds for the cluster characterized by incidence of

  • multiple metabolic abnormalities (OR 1.97 [95% CI 1.18, 3.30] for sleep duration and

  • OR 2.10 [95% CI 1.25, 3.53] for sleep timing).

CONCLUSIONS Increased variability in sleep duration and timing was associated with higher prevalence and incidence of metabolic abnormalities even after considering sleep duration and other lifestyle factors.

Tags: Metabolic Syndrome Sleep