Poor genes (DBP, CYP24A1, CYP2R, etc.) restrict Vitamin D to cells, increasing COVID hospitalization

Association of Vitamin D Status and COVID-19-Related Hospitalization and Mortality

Gen Intern Med. 2022. https://doi.org/10.1007/s11606-021-07170-0. – Letter to the Editor

Marijn M. Speeckaert MD, PhD & Joris R. Delanghe MD, PhD

With interest, we read the paper of Seal et al.,1 which investigated the association of vitamin D status and COVID-19-related hospitalization and mortality. 25-Hydroxyvitamin D [25(OH)D] concentrations were connected in an inverse dose-response relationship to COVID-19-related hospitalization and mortality in a heterogeneous population of veteran patients. Although various confounders were considered, we want to emphasize the significance of vitamin D–binding protein (DBP) and its polymorphism on the obtained results.

Normally, 25(OH)D circulates mainly bound to DBP (approximately 85%) and albumin (15%), while only 0.03% exists in free form. DBP is the main transporter of vitamin D metabolites, and an extensive DBP polymorphism with a distinct allele distribution in various geographic areas has been identified.2 The genetic polymorphisms rs7041 and rs4588 in exon 11 of the DBP gene identify the three major DBP alleles: DBP1F [rs7041-T (ASP), rs4588-C (Thr)], DBP1S [rs7041-G (ASP), rs4588-C (Thr)], and DBP2 [rs7041-T (ASP), rs4588-A (Lys)].2,3 rs2282679 is an rs4588 proxy, and rs2282679-A is generally coinherited with rs4588-C, whereas rs2282679-C is usually coinherited with rs4588-A.4 The concentrations of free and total 25(OH)D, as well as DBP, increase with the following phenotypes: DBP2-2vitamind)}SELECT COUNT(*) FROM (SELECT catObjectId, COUNT(*) FROM tiki_category_objects WHERE categId = 155 OR categId = 72 GROUP BY catObjectId HAVING COUNT(*) > 1) AS categs INNER JOIN tiki_objects ON tiki_objects.objectId = categs.catObjectId WHERE type = "wiki page"{SQL} --> Virus and Genetics

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  1. The letter failed to mention the Vitamin D Receptor- which is deactivated by most   virusus

  1. VitaminDWiki -  <!-- {SQL(db=>vitamind)}SELECT COUNT(*) FROM (SELECT catObjectId, COUNT(*) FROM `tiki_category_objects` WHERE categId = 155  OR categId = 142 GROUP BY catObjectId HAVING COUNT(*) > 1) AS categs INNER JOIN tiki_objects ON tiki_objects.objectId = categs.catObjectId WHERE type = "wiki page"{SQL} --> studies in both categories Virus and Vitamin D Receptor

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  1. VitaminDWiki -  <!-- {SQL(db=>vitamind)}SELECT COUNT(*) FROM (SELECT catObjectId, COUNT(*) FROM `tiki_category_objects` WHERE categId = 155  OR categId = 143 GROUP BY catObjectId HAVING COUNT(*) > 1) AS categs INNER JOIN tiki_objects ON tiki_objects.objectId = categs.catObjectId WHERE type = "wiki page"{SQL} --> studies in both categories Virus and DBP

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  1. VitaminDWiki Virus pages with CYP24A1 in title

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