Perhaps Stress fractures 2X less frequent if 4000 IU of vitamin D

Created June 2011

High serum 25-hydroxyvitamin D is associated with low incidence of stress fractures.

J Bone Miner Res. 2011 Jun 22. doi: 10.1002/jbmr.451.

Burgi AA, Gorham ED, Garland CF, Mohr SB, Garland FC, Zeng K, Thompson K, Lappe JM.

Naval Health Research Center, San Diego, California.

BACKGROUND: Low serum 25-hydroxyvitamin D [25(OH)D] concentrations are associated with hip fractures, but the dose-response relationship of serum 25(OH)D with risk of stress fractures in young women is unknown.

OBJECTIVE: This nested case-control study in a cohort of female Navy recruits was designed to determine if those with low prediagnostic serum 25(OH)D concentrations had greater risk of stress fracture.

DESIGN: Sera were drawn in 2002-2009 from 600 women who were subsequently diagnosed with stress fracture of the tibia or fibula, and 600 matched controls, who did not experience a stress fracture. The 25(OH)D concentration was measured using the DiaSorin radioimmunoassay method. Controls were individually matched to cases on race (White, Black, or other); length of service (± 30 days); and day blood was drawn (± 2 days).

RESULTS: There was approximately half the risk of stress fracture in the top compared to bottom quintile of serum 25(OH)D concentration (OR?=?0.51, 95% CI 0.34-0.76, p??40?ng/ml, achievable with 4000 IU/day vitamin D(3) supplementation.

PMID: 21698667

Young women with average 50 ng of vitamin D had 1/2 the fractures as those with average 14 ng

Suggests taking 4000 IU of vitamin D

Perhaps Stress fractures 2X less frequent if 4000 IU of vitamin D

High serum 25-hydroxyvitamin D is associated with low incidence of stress fractures.

See also VitaminDWiki