People with new fecal incontinence are 1.9 X more likely to have low Vitamin D
The association between vitamin-D deficiency and fecal incontinence
Neurogastroenterol Motil 2024 Feb 5:e14753. doi: 10.1111/nmo.14753 PDF can be viewed at DeepDyve
Leila Neshatian 1, Gabrielle Grant 2, Nielsen Fernandez-Becker 1, Ye Yuan 3, Patricia Garcia 1, Laren Becker 1, Brooke Gurland 4, George Triadafilopoulos 1
Background: Vitamin-D is essential for musculoskeletal health. We aimed to determine whether patients with fecal incontinence (FI): (1) are more likely to have vitamin-D deficiency and, (2) have higher rates of comorbid medical conditions.
Methods: We examined 18- to 90-year-old subjects who had 25-hydroxy vitamin-D levels, and no vitamin-D supplementation within 3 months of testing, in a large, single-institutional electronic health records dataset, between 2017 and 2022. Cox proportional hazards survival analysis was used to assess association of vitamin-D deficiency on FI.
Key results: Of 100,111 unique individuals tested for serum 25-hydroxy vitamin-D, 1205 (1.2%) had an established diagnosis of FI. Most patients with FI were female (75.9% vs. 68.7%, p = 0.0255), Caucasian (66.3% vs. 52%, p = 0.0001), and older (64.2 vs. 53.8, p < 0.0001).
Smoking (6.56% vs. 2.64%, p = 0.0001) and
GI comorbidities, including
constipation (44.9% vs. 9.17%, p = 0.0001),
irritable bowel syndrome (20.91% vs. 3.72%, p = 0.0001), and
diarrhea (28.55% vs. 5.2%, p = 0.0001)
were more common among FI patients.
Charlson Comorbidity Index score was significantly higher in patients with FI (5.5 vs. 2.7, p < 0.0001). Significantly higher proportions of patients with FI had vitamin-D deficiency (7.14% vs. 4.45%, p < 0.0001). Moreover, after propensity-score matching, rate of new FI diagnosis was higher in patients with vitamin-D deficiency; HR 1.9 (95% CI [1.14-3.15]), p = 0.0131.
Conclusion & inferences: Patients with FI had higher rates of vitamin-D deficiency along with increased overall morbidity. Future research is needed to determine whether increased rate of FI in patients with vitamin-D deficiency is related to frailty associated with increased medical morbidities.
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VitaminDWiki – Overview Gut and vitamin D has
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VitaminDWiki – Overview Gut and vitamin D contains gut-friendly information
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VitaminDWiki – Gut category listing contains
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VitaminDWiki – Irritable Bowel Syndrome and Vitamin D - many studies
VitaminDWiki – Constipation - Magnesium, Calcium and cofactors
Note: Vitamin D both consumes Magnesium and Increases Calcium