Partial (proximal) hip fracture strongly associated with low Vitamin D
Elderly with proximal hip fracture present significantly lower levels of 25-hydroxyvitamin D.
Rev Bras Ortop. 2016 Aug 31;51(5):583-588.
Guerra MT1, Feron ET2, Viana RD2, Maboni J2, Pastore SI2, Castro CC2.
1 Universidade Luterana do Brasil (Ulbra), Departamento de Ortopedia e Traumatologia, Canoas, RS, Brazil; Universidade Luterana do Brasil (Ulbra), Hospital Universitário Mãe de Deus, Serviço de Ortopedia e Traumatologia, Canoas, RS, Brazil.
2 Universidade Luterana do Brasil (Ulbra), Hospital Universitário Mãe de Deus, Serviço de Ortopedia e Traumatologia, Canoas, RS, Brazil.
Hip fracture | Controls | | Deficient | 55% | 30% | | Insufficient | 27% | 31% | | Sufficient | 18% | 39% | See also VitaminDWiki * Hip fractures reduced 2X to 6X with just 10 minutes of sunlight daily – RCT 2003-2010 * Bone fractures in children requiring surgery were 55X more likely with low vitamin D – June 2015 * Hospital found that Vitamin D saves money by improving bone fracture healing– March 2016 * Save 2 billion dollars annually in fractures if take Vitamin D and Calcium – Frost and Sullivan Sept 2013 * Overview Fractures and vitamin D * All items in category Falls or Fractures and Vitamin D ** items* * Meta-analyses of Falls and Fracture in VitaminDWiki {category}
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OBJECTIVE:
To compare serum 25-hydroxyvitamin D (25[OH]D) levels, a serum marker of vitamin D3, between patients with and without proximal hip fracture.
METHODS:
This was a case-control study in which serum samples of 25(OH)D were obtained from 110 proximal hip fracture inpatients and 231 control patients without fractures, all over 60 years of age. Levels of 25(OH)D lower than or equal to 20 ng/mL were considered deficient; from 21 ng/mL to 29 ng/mL, insufficient; and above 30 ng/mL, sufficient. Sex, age, and ethnicity were considered for association with the study groups and 25(OH)D levels.
RESULTS:
Patients with proximal hip fracture had significantly lower serum 25(OH)D levels (21.07 ng/mL) than controls (28.59 ng/mL; p = 0.000). Among patients with proximal hip fracture, 54.5% had deficient 25(OH)D levels, 27.2% had insufficient levels, and only 18.2% had sufficient levels.
In the control group, 30.3% of patients had deficient 25(OH)D levels, 30.7% had insufficient levels, and 38.9% had sufficient levels. Female patients had decreased serum 25(OH)D levels both in the fracture group and in the control group (19.50 ng/mL vs. 26.94 ng/mL; p = 0.000) when compared with male patients with and without fracture (25.67 ng/mL vs. 33.74 ng/mL; p = 0.017). Regarding age, there was a significant association between 25(OH)D levels and risk of fracture only for the age groups 71-75 years and above 80 years.
CONCLUSION:
Patients with proximal hip fracture had significantly decreased serum 25(OH)D levels when compared with the control group. Female patients had significantly lower serum 25(OH)D levels in both groups.
PMID: 27818981 DOI: 10.1016/j.rboe.2016.08.013