Overview of Vitamin D Actions in Cancer – 31 page chapter in a book – 2018

Chapter 94 - Overview of Vitamin D Actions in Cancer

Vitamin D (Fourth Edition), Volume 2: Health, Disease and Therapeutics, 2018, Pages 711-742

https://doi.org/10.1016/B978-0-12-809963-6.00094-8

Throughout the last 2 or 3 decades it has become evident that vitamin D has effects beyond calcium and bone metabolism. A wide variety of cells and tissues are affected by vitamin D. These targets include tumor cells and the findings have led to a vast series of studies on the actions of vitamin D on cell growth regulation, treatment of cancer and development of potent synthetic vitamin D analogues as inhibitors of cancer cell growth. Various specialized chapters in this book will discuss in detail the effects of vitamin D on specific cancers. In this chapter our goal is to set the stage by providing an overview of the history and current state of knowledge of the field. We will address several areas: recent developments in studies of vitamin D and cancer, regulation of tumor cells, possible mechanisms, and clinical applications.

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TABLE 94.1Vitamin D Receptor in Tumors and Malignant Cell Types

Basal Cell Carcinoma

Breast Carcinoma

Bladder Cancer

Cervical Carcinoma

Colonic Adenocarcinoma

Colorectal Carcinoma

Gall Bladder Carcinoma

Glioblastoma

Kaposi Sarcoma

Lung Carcinoma

Lymphocytic Leukemia

Malignant B-Cell Progenitors

Malignant Melanoma

Medullary Thyroid Carcinoma

Myeloid Leukemia

Multiple Myeloma

Osteogenic Sarcoma

Ovarian Carcinoma

Neuroblastoma

Non-Hodgkin’s Lymphoma

Pancreatic Carcinoma

Parathyroid Adenoma

Pituitary Adenoma

Prostate Carcinoma

Renal cell Carcinoma

Squamous cell Carcinoma

Transitional cell Bladder Carcinoma

Uterine Carcinosarcoma

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