Osteoporosis treatment with denosumab is helped by Vitamin D and Calcium – 2017
Vitamin D and calcium are required at the time of denosumab administration during osteoporosis treatment Oct 2017
Bone Res. 2017 Oct 10;5:17021. doi: 10.1038/boneres.2017.21. eCollection 2017.
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Nakamura Y1,2, Suzuki T1, Kamimura M3, Murakami K1, Ikegami S1, Uchiyama S1, Kato H1.
1 Department of Orthopedic Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
2 Department of Orthopedic Surgery, Showa-Inan General Hospital, Komagane, Japan.
3 Center of Osteoporosis and Spinal Disorders, Kamimura Orthopaedic Clinic, Matsumoto, Japan.
To evaluate the differences in outcomes of treatment with denosumab alone or denosumab combined with vitamin D and calcium supplementation in patients with primary osteoporosis. Patients were split into a denosumab monotherapy group (18 cases) or a denosumab plus vitamin D supplementation group (combination group; 23 cases). We measured serum bone alkaline phosphatase (BAP), tartrate-resistant acid phosphatase (TRACP)-5b and urinary N-terminal telopeptide of type-I collagen (NTX) at baseline, 1 week, as well as at 1 month and 2, 4, 8 and 12 months. We also measured bone mineral density (BMD) of L1-4 lumbar vertebrae (L)-BMD and bilateral hips (H)-BMD at baseline and at 4, 8 and 12 months. There was no significant difference in patient background. TRACP-5b and urinary NTX were significantly suppressed in both groups from 1 week to 12 months (except at 12 months for NTX). In the combination group, TRACP-5b was significantly decreased compared with the denosumab monotherapy group at 2 and 4 months (P<0.05). BAP was significantly suppressed in both groups at 2-12 months. L-BMD significantly increased at 8 and 12 months (8.9%) in the combination group and at 4, 8 and 12 months (6.0%) in the denosumab monotherapy group, compared with those before treatment. H-BMD was significantly increased in the combination group (3.6%) compared with the denosumab group (1.2%) at 12 months (P<0.05). Compared with denosumab monotherapy, combination therapy of denosumab with vitamin D and calcium stopped the decrease in calcium caused by denosumab, inhibited bone metabolism to a greater extent, and increased BMD (especially at the hips).
PMID: 29021920 PMCID: PMC5634512 DOI: 10.1038/boneres.2017.21
They used a very small amount of Vitamin D (400 IU daily)
"762.5 mg of precipitated calcium carbonate, 200 IU of cholecalciferol, 59.2 mg of magnesium carbonate) twice daily to all patients after denosumab administration"
Imagine the increase in bone density if they had used a lot of Vitamin D, Magnesium, Silicon, Boron and Vitamin K which are needed to build bones
See VitaminDWiki
Healthy bones need: Calcium, Vitamin D, Magnesium, Silicon, Vitamin K, and Boron – 2012
Vitamin D, K2, Magnesium, etc increase bone density when taking together– Jan 2012