Osteoporosis quality of life better if more than 20 ng of vitamin D

Created January 2014

Serum 25-Hydroxyvitamin D Level as an Independent Determinant of Quality of Life in Osteoporosis With a High Risk for Fracture☆

Hiroaki Ohta, MD, PhD, Yukari Uemura, PhD, Toshitaka Nakamura, MD, PhD, Masao Fukunaga, MD, PhD, Yasuo Ohashi, PhD, Takayuki Hosoi, MD, PhD, Satoshi Mori, MD, PhD, Toshitsugu Sugimoto, MD, PhD, Eiji Itoi, MD, PhD, Hajime Orimo, MD, PhD, Masataka Shiraki, MD, PhDemail address, for the Adequate Treatment of Osteoporosis (A-TOP) Research Group

Background: Deteriorated quality of life (QOL) is a major problem in osteoporotic women. However, little is known regarding the determinants of QOL in patients with osteoporosis.

Objective: Our aim was to explore the role of vitamin D status on QOL score in osteoporosis with high fracture risk.

Methods

Patients were osteoporotic women aged ≥70 years and with ≥1 risk factor for incident fracture, namely prevalent osteoporotic fracture, bone mineral density (BMD) >–3.0 SD of young adult mean, or high bone turnover marker. Health-related QOL was assessed using the Japanese Osteoporosis Quality of Life Questionnaire (JOQOL). When patients were classified into quartiles by total QOL score). Serum 25-hydroxyvitamin D (25[OH]D) level was measured by immunoassay.

Results

A total of 1585 osteoporotic women were included in the study (age range, 70–95 years). Age, body mass index, serum 25(OH)D status (low, normal, or high), bone mineral density, number of prevalent vertebral fractures, presence of hypertension, presence of osteoarthritis, and history of falls were significantly correlated with QOL quartile. Multivariate liner regression analysis indicated that low serum 25(OH)D level (<20 ng/mL) was an independent determinant of total QOL score quartile (P = 0.0055).

The conventional determinants of

  • QOL—age (P < 0.0001),

  • body mass index (P = 0.0060),

  • number of prevalent vertebral fractures (P < 0.0001),

  • presence of osteoarthritis (P = 0.0074), and

  • history of fall (P = 0.0098)

    • were also independent determinants of total QOL score.

Conclusions

These results strongly suggest that low serum 25(OH)D level was a significant determinant of QOL in these osteoporotic women, independently of the conventional factors that reduce QOL. Maintenance of serum 25(OH)D levels >20 ng/mL may be required to maintain patients’ QOL in osteoporosis.

See also VitaminDWiki

Overview Osteoporosis and vitamin D contains the following summary

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Tags: Osteoporosis