Need more than 2,000 IU daily to get obese people to 30 ng level of vitamin D (not a surprise) – review

Optimal dosage of vitamin D supplementation in obese patients with low serum levels of 25-Hydroxyvitamin D. A systematic review

Obesity Medicine, Volume 29, January 2022, 100381, https://doi.org/10.1016/j.obmed.2021.100381

Claudia A.Pered aa M. BetinaNishishiny ab

Aims

The purpose of this study was to assess the evidence for an appropriate dose-response of vitamin D supplementation in patients with obesity with inadequate vitamin D serum levels.

Methods

We performed a systematic review consulting Medline, Embase and Cochrane Library up to September 2020 to identify studies that included (1) adult obese individuals with vitamin D serum levels below 75 nmol/l, (2) receiving cholecalciferol or calcidiol therapy (3) vitamin D serum levels assessment.

Results

The electronic search identified 705 potentially eligible studies, 11 of which were included and analysed. The heterogeneity of the studies did not permit a meta-analysis. Five studies (45.5%) were of high quality. Oral daily cholecalciferol resulted the route of administration that prevailed in most studies. We found that a minimum dose of =>2000UI/day might be needed to normalize 25OHD serum levels. Conversely, oral calcidiol <300IU/day failed to achieve 25OHD sufficiency.

Conclusions

Exposed evidence suggests that vitamin D requirements remain higher in patients with obesity compared to lean patients. In order to normalize 25OHD serum levels, patients taking cholecalciferol might need to triple the actual recommended vitamin D doses. In contrast, calcidiol doses are still to be clarified.

---

VitaminDWiki - Overview Obesity and Vitamin D contains the following summary

{include}

{include}

---

VitaminDWiki - Obesity is associated with low Vitamin D (and treated by D as well) – Aug 2019 has

{include}

---

Vitamin D Intervention AND Obesity

{category}