Multiple Sclerosis fatigue reduced by weekly Vitamin D (50,000 IU)
Effect of Vitamin D Supplementation on Fatigue in Multiple Sclerosis: A Systematic Review and Meta-Analysis
Nutrients. 2023 Jun 24;15(13):2861. doi: 10.3390/nu15132861.
Purificación López-Muñoz 1 2, Ana Isabel Torres-Costoso 1 3, Rubén Fernández-Rodríguez 3, María José Guzmán-Pavón 1, Sergio Núñez de Arenas-Arroyo 3, Julián Ángel Basco-López 1 2, Sara Reina-Gutiérrez 3
With 1296 trials to select from,
they managed to include a trial that used an impossibly small 40 IU of Vitamin D
Vitamin D supplementation has been considered a possible treatment to reduce the risk of disease activity and progression in people with multiple sclerosis (MS). However, its effect on disease symptoms remains unclear. The aim of this meta-analysis was to conduct a systematic review to assess the effect of vitamin D on fatigue in this population. The systematic review was conducted using the MEDLINE, Cochrane Library, Embase and Web of Science databases from inception to May 2023. Randomized controlled trials (RCTs) reporting pre-post changes in fatigue after vitamin D supplementation were included. Pooled effect sizes and 95% confidence intervals (95% CIs) were calculated by applying a random effects model with Stata/SE (Version 16.0; StataCorp., College Station, TX, USA). The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. A total of five studies with 345 individuals (271 females; age range: 25.4-41.1 years) were included. A significant reduction in fatigue was perceived when vitamin D supplementation was compared with a control group: -0.18 (95% CI: -0.36 to -0.01; I2 = 0%). Thus, our findings show that the therapeutic use of vitamin D on fatigue in people with MS could be considered. Nevertheless, due to the lack of agreement on the dose to be applied, it is recommended to use it under medical prescription.
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VitaminDWiki – Weekly dosing is Better than Daily contains:
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VitaminDWiki – Overview MS and vitamin D contains
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Note: The 50,000 IU study included aerobic exercise
Bahmani, E.; Hoseini, R.; Amiri, E. The effect of home-based aerobic training and vitamin D supplementation on fatigue and quality of life in patients with multiple sclerosis during COVID-19 outbreak. Sci. Sports 2022, 37, 710–719.
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229+ VitaminDWiki pages have 50,000 or 60,000 IU in their title
Note: India uses 60,000 IU capsules
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