Malabsorption syndromes and low vitamin D (interesting, behind 6 dollar paywall)

Deficiencies of vitamin D in patients with intestinal malabsorption syndromes: Think in and outside of the gut

Journal of Digestive Diseases, DOI: 10.1111/1751-2980.12283

Samantha Margulies1, Divya Kurian1, Mark S Elliott2 andZhiyong Han2,*

There is a considerable high prevalence of vitamin D deficiency, which is defined by the serum level of 25-hydroxyvitamin D [25(OH)D] lower than 20 ng/ml, in all populations of the world. Unfortunately, the prevalence of vitamin D deficiency in patients with intestinal malabsorption syndromes, including

• cystic fibrosis (CF),

• celiac disease (CD),

• short bowel syndrome, and

• inflammatory bowel disease (IBD),

is higher than that in the general population, indicating the presence of disease-specific causative factors.

In this review, we aim to present clinical findings to highlight the roles of insufficient sunlight exposure and inflammation in the development of vitamin D deficiency in patients with intestinal malabsorption syndromes.

Also, we aim to present experimental evidence that supports a role of vitamin D deficiency in the pathogenesis of IBD.

Finally, we review clinical intervention strategies that aim to normalize vitamin D status in and/or even improve the conditions of patients and discuss certain issues that need to be addressed in future research.

This article is protected by copyright. All rights reserved.

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