Lyme disease and Vitamin D Receptor - many studies
Lyme, COVID, and various cancers have learned to protect themselves by deactivating the Vitamin D receptor.
Receptor deactivation is not detectable by standard vitamin D tests, a person with Lyme disease
- can have a good blood level of vitamin D but a poor level of vitamin D in tissues.
The poor activation can result in many other health problems, such as autoimmune diseases
There are many ways to restore the activation of the Vitamin D receptor
- Person with Lyme should try VDR activators
đź“„ Resveratrol and Curcumin have been found to help
- Person with Lyme should try VDR activators
bloodthirsty ticks give lyme disease to animals, pets, and humans
Lyme Disease Blocks Vitamin D Absorption by 80 X - video March 2024
Lyme disease reduced Vitamin D Receptor by 8X to 50X - June 2019
Vitamin D Receptor - activation and deactivation- self-hacked June 2019
Lyme/Borrelia – Live Borrelia reduces VDR by 50 times (in monocytes) and “dead” Borrelia reduces it by 8 times 63
- This could explain why people develop autoimmune conditions after Lyme infection.
Half of NE US Ticks have Lyme Disease - Jan 2025
Vitamin D Receptor - reduced by Lyme, easily restored by supplements
Chronic Lyme disease - includes VDR Feb 2019
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Borrelia and the VDR
In the arms race of host–microbe co-evolution, successful microbial pathogens have evolved ingenious ways to evade host immune responses.9)
Studies have indicated that the dysregulation of VDR may lead to exaggerated inflammatory responses, raising the possibility that defects in Vitamin D and VDR signaling transduction may be linked to bacterial infection and chronic inflammation. Further characterization of Vitamin D/VDR will help elucidate the pathogenesis of various human diseases and in the design of new approaches for prevention and treatment. Jun Sun 10)
Since the VDR is at the heart of the innate immune system, bacteria can survive by discovering how to disable it through a variety of different actions. Actions accumulate and are more powerful than individual actions. In keeping with evolutionary theory, a growing number of substances and species have been shown to downregulate the activity of the VDR, one of which is Borrelia burgdorferi. Live Borrelia burgdorferi reduced VDR expression in monocytes (phagocytes) by 50 times, and lysates (“dead” Borrelia) reduced it by 8 times 11)
8) Human Tick-Borne Diseases in Australia., Dehhaghi M, Kazemi Shariat Panahi H, Holmes EC, Hudson BJ, Schloeffel R, Guillemin GJ, Front Cell Infect Microbiol9p3(2019)
9) Microbial manipulation of receptor crosstalk in innate immunity. Hajishengallis G, Lambris JD, Nat Rev Immunol11p187-200(2011 Mar)
10) Vitamin D and mucosal immune function. Sun J, Curr Opin Gastroenterolp(2010 Jul 15) đź“„ Download the PDF from VitaminDWiki
11) Activation of human monocytes by live Borrelia burgdorferi generates TLR2-dependent and -independent responses which include induction of IFN-beta. Salazar JC, Duhnam-Ems S, La Vake C, Cruz AR, Moore MW, Caimano MJ, Velez-Climent L, Shupe J, Krueger W, Radolf JD, PLoS Pathog5pe1000444 (2009 May) đź“„ Download the PDF from VitaminDWiki
Lyme Disease and Vitamin D Receptor Activators
Note: I do not have Lyme Disease, but have a poor vitamin D receptor
Nature's Essentials Resveratrol 500mg is an Amazon Resveratrol with high bio-availability which I have been taking
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Diseases associated with a poor Vitamin D Receptor
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Vitamin D Receptor Activators
Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 13 known VDR activators
VitaminDWiki - Vitamin D Receptor deactivated by some health problems - many studies
Have any of the following been found to prevent or treat Lyme Disease: Resveratrol Omega-3 Magnesium Zinc Quercetin Curcumin Berberine Butyrate Sulforaphane Ginger "Essential oils" "intense exercise"?
Perplexity (using CLAUDE 3.5 SONNET Oct 2024)
Based on the available research, here's what we know about the potential of those compounds for preventing or treating Lyme disease:
Resveratrol
Resveratrol, found in Japanese knotweed, has shown some promise:
It has antimicrobial and anti-inflammatory properties that may help against Lyme disease 1 5
A 2020 Johns Hopkins study found Japanese knotweed extract had greater activity against Borrelia burgdorferi (the Lyme bacteria) than some antibiotics 5
Resveratrol appears safe at typical supplement doses, though it may have blood-thinning effects 5
Other Compounds
Omega-3, magnesium, zinc, quercetin, curcumin: Â While these have general anti-inflammatory properties, there's no strong evidence specifically for Lyme disease prevention or treatment.
Berberine: Â Some preliminary research suggests potential antimicrobial activity, but more studies are needed on its effects for Lyme disease.
Butyrate, sulforaphane, ginger: Â No significant evidence was found regarding their use for Lyme disease.
Essential oils: Â Oregano and thyme oils have shown some in vitro activity against B. burgdorferi, but clinical evidence is lacking 6
Exercise
While exercise may have general health benefits, there's no evidence that "intense exercise" specifically prevents or treats Lyme disease.
Key Points
None of these compounds are proven treatments for Lyme disease.
The most effective prevention methods remain avoiding tick bites and prompt tick removal 8
Antibiotics are the standard treatment for diagnosed Lyme disease 8
It's important to consult with a healthcare provider for proper diagnosis and treatment of Lyme disease rather than relying solely on supplements or alternative remedies.
20,000 hits as of April 2025 on VDR activators and Lyme Disease
Synergistic Antimicrobial Potential of Herbal and Essential Oil Compounds Against Borrelia burgdorferi and Other Bacterial Pathogens Jan 2025 Resveratrol occurs 9 times
Characteristics of Clinics Offering Nontraditional Lyme Disease Therapies in Lyme Endemic States of the United States - Jan 2025 FREE PDF
- scores of therapies are described - costing $200 to $2,000. No mention of vitamin D receptor
A Comprehensive Review of Herbal Supplements Used for Persistent Symptoms Attributed to Lyme Disease March 2023 FREE PDF
Lost in Lyme: The Therapeutic Use of Medicinal Plants in Supporting People with Lyme Disease Amazon book Google preview of book
Recovery from Lyme Disease: The Integrative Medicine Guide to Diagnosing and Treating Tick-Borne Illness - 2021 Amazon
The Use of Natural Bioactive Nutraceuticals in the Management of Tick-Borne Illnesses - July 2023 FREE PDF
Plants supporting the treatment of Lyme disease - Sept 2023 FREE PDF
Liberating Yourself from Lyme: An Integrative and Intuitive Guide to Healing Lyme Disease Jan 2021 Amazon Book  Google look inside of the book
See also – Resveratrol improves health
Lyme Disease - 500,000 Americans annually - more than Breast Cancer - Mercola Sept 2024
" There are more cases of Lyme disease than HIV and breast cancer combined.
Of those 500,000, about 10% to 20% will stay sick for some period of time . We now believe that something on the order of 2 million people suffer the aftereffects of Lyme disease in the United States."The phrase "Vitamin D" does not occur once
See also: Lyme and Vitamin D on the web
In-depth coverage of Lyme disease - 2024 FREE PDF
Five Common Nutritional Deficiencies In People With Chronic Lyme Disease April 2016
- Vitamin D3, Magnesium, Zinc
What's the deal with Vitamin D? LymeMD 2008
Appears that people trying to treat Lyme with just daily vitamin D get to toxic levels without any benefit
No mention of the Vitamin D Receptor which woul greatly reduce the amount of Vitamin D needed
- "According to the U.S. Centers for Disease Control and Prevention (CDC), an estimated 329,000 Americans are diagnosed with Lyme disease each year, although some data suggest it may actually be over 444,000.1 While exact numbers are difficult to ascertain, what is known is that the prevalence is rising."
Lyme Disease rate increased 4X in 28 years
Possible reasons for increase include:
- lower D in population,
- increasing rate of poor Vitamin D Receptor,
- warmer climate
- more ticks
Lyme Disease Is Baffling, Even to Experts
Took 16 years to get her problem correctly diagnosed
"Reported cases increased almost fivefold from 1992 to 2017, and the Centers for Disease Control and Prevention estimates that annual incidences have risen to more than 300,000, and may even range above 400,000"
"After 40 years in the public-health spotlight, Lyme disease still can’t be prevented by a vaccine; eludes reliable testing; and continues to pit patients against doctors, and researchers against one another."
"A significant percentage of people who had Lyme symptoms and later tested positive for the disease had never gotten the rash. Others had many characteristic symptoms but tested negative for the infection, and entered treatment anyway. Most startling, a portion of patients who had been promptly and conclusively diagnosed with Lyme disease and treated with the standard course of doxycycline didn’t really get better."
Lyme Disease Map 2022
Map 2015
It's Time to Get Serious about Tick-Borne Diseases - Scientific American Aug 2019
Scientific American Vitamin D NOT mentioned
"Today another epidemic rages unchecked: the number of Lyme disease cases has doubled since 2004, for a total of over 400,000."
"At least 10 to 20 percent stay sick for a year, with 5 percent still suffering 15 years later—this among patients receiving early treatment, who have the best outcomes"
67 Lyme Disease Clinical trials as of 2019
"In 2017, mosquito-borne West Nile virus, which currently infects about 2,000 people annually in the U.S. received $42 million in support from the U.S. National Institutes of Health. Lyme disease, with 20 times the number of reported cases, got half as much, a figure that has changed little in a decade"
Lyme Disease charts on the web
https://www.instagram.com/explore/search/keyword/?q=lyme%20diseqse
