Lungs with cystic fibrosis fail to activate vitamin D (poor CYP27B)

Cystic fibrosis bronchial epithelial cells have impaired ability to activate Vitamin D.

Acta Paediatr. 2016 Feb 10. Doi: 10.1111/apa.13361. [Epub ahead of print]

Pincikova T1,2,3, Svedin E3, Domsgen E3, Flodström-Tullberg M3, Hjelte L1,2.

• 1 Stockholm CF Center, Karolinska University Hospital Huddinge, Stockholm, Sweden.

• 2 Division of Pediatrics, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.

• 3 Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.

The vitamin D receptor system is widely expressed in the human body, including immune system cells and epithelial cells (1). The enzyme responsible for the second hydroxylation step in the production of active vitamin D, 1alpha-hydroxylase (Cyp27B), is not just expressed in the kidneys, as previously thought (2).

Primary lung epithelial cells have been shown to activate vitamin D (3). The focus of recent vitamin D research has been to test the effect of the active form of vitamin D in vitro (4-6) and this has led to increased knowledge about the role of active vitamin D in the immune system and in antimicrobial defence. The picture that has emerged from studies strongly suggests that active vitamin D has an important function in regulating inflammation and infection, including in cystic fibrosis (5-6).

PMID: 26865115 PDF is available in DeepDyve.com

Reference #3

Respiratory Epithelial Cells Convert Inactive Vitamin D to its Active Form - 2008

📄 Download the PDF from VitaminDWiki

Respiratory epithelium Wikipedia

See also VitaminDWiki

• items in CYP27B1 category

• Mutation of Vitamin D gene (CYP27B1) is strongly tied to MS – Dec 2011

• Colon cancer 30 percent more likely if problems with Vitamin D genes CYP24A1 or CYP27B1 – Nov 2015

• UVB increases vitamin D even if poor kidney by changing CYP27B1 genes in skin – Dec 2013

• Genes such as CYP27B1, CYP24A1 and Vitamin D – JAMA Nov 2012

• 3X higher risk of oral cancer if CYP27B1 and CYP24A1 genes were different – May 2012

Cystic Fibrosis category page in VitaminDWiki follows:

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