Low Magnesium results in poor health (Breast Cancer in this case)

Created November 2019

Low Magnesium results in poor health - GRH Nov 2019

How Magnesium Could Impact Cancer Risk GrassrootsHealth Nutrient Institute

image

Direct and indirect associations between dietary magnesium intake and breast cancer risk - 2019

Sci Rep. 2019 Apr 8;9(1):5764. doi: 10.1038/s41598-019-42282-y.

Huang WQ1,2, Long WQ3, Mo XF4, Zhang NQ1, Luo H1, Lin FY5, Huang J1, Zhang CX6,7.

Associations shown include Mg: Ca, but not Mg:Vitamin D

image

This study aimed to explore the effect of dietary magnesium intake on breast cancer risk both directly and indirectly via its effect on inflammatory markers C-reactive protein (CRP) and interleukin-6 (IL-6). This case-control study recruited 1050 case patients and 1229 control subjects. Inflammatory marker levels of 322 cases and 322 controls, randomly selected, were measured using ELISA, and data on dietary magnesium intake were collected using a food frequency questionnaire. Multivariable logistic regression was used to estimate the odds ratio (OR) and 95% confidence interval (CI), and path analysis was used to investigate the mediating effect. A higher magnesium intake was associated with a lower breast cancer risk (adjusted OR = 0.80, 95% CI = 0.65, 0.99). A positive association was found between the CRP level and breast cancer risk (adjusted OR = 1.43, 95% CI = 1.02-2.01). However, IL-6 was not found to be associated with breast cancer risk. Path analysis revealed that dietary magnesium affected breast cancer risk both directly and indirectly by influencing the CRP level. The results indicate that a direct negative association and an indirect association through influencing the CRP level were observed between dietary magnesium intake and breast cancer risk.

See also VitaminDWiki

Magnesium and Vitamin D contains the following summary

{include}

Overview Magnesium and vitamin D Has a venn diagram of relationship of Mg and Vit D

{include}

Magnesium and some other Health categories in VitaminDWiki

Magnesium and Breast Cancer

{category}

Magnesium and other Cancers

{category}

Magnesium and Cardiovascular

{category}

Magnesium and Diabetes

{category}

Magnesium and Obesity

{category}

Magnesium in Breast Cancer: What Is Its Influence on the Progression of This Disease? - Aug 2018

Biol Trace Elem Res. 2018 Aug;184(2):334-339. doi: 10.1007/s12011-017-1207-8

Mendes PMV1, Bezerra DLC1, Dos Santos LR1, de Oliveira Santos R1, de Sousa Melo SR1, Morais JBS1, Severo JS1, Vieira SC2, do Nascimento Marreiro D3.

  • 1 Department of Nutrition, Federal University of Piauí, Ministro Petrônio Portella Campus, Ininga, Rua Hugo Napoleão, 665, Ed. Palazzo Reale, Apt°. 2001, Jóquei, Teresina, PI, CEP 64048-320, Brazil.

  • 2 Department of Medicine, Federal University of Piauí, Ministro Petrônio Portella Campus, Ininga, Teresina, PI, Brazil.

  • 3 Department of Nutrition, Federal University of Piauí, Ministro Petrônio Portella Campus, Ininga, Rua Hugo Napoleão, 665, Ed. Palazzo Reale, Apt°. 2001, Jóquei, Teresina, PI, CEP 64048-320, Brazil. dilina.marreiro@gmail.com.

Breast cancer is a disease of high mortality, characterized by the progressive accumulation of mutations that contribute to the uncontrolled development of breast tissue cells. Literature shows that disturbances in mineral homeostasis, such as magnesium, may interfere with tumor progression. The objective of this study is to provide updated information about magnesium's role in the pathogenesis of breast cancer. A review of literature was carried out from a search for articles in the PubMed and CAPES Periodicals databases published between 1995 and 2016 with the cross-references of the descriptors "magnesium," "breast neoplasms," and "oxidative stress" and the corresponding words in Portuguese. We included studies on the metabolism and bioavailability of magnesium and studies related to breast cancer and excluded articles in which only the abstract was available, dissertations, theses, articles involving adjuvant and/or neoadjuvant therapies, and supplementation of minerals in breast cancer patients. Magnesium is a mineral that participates in the metabolism of various nutrients and nucleic acids.

In the presence of breast cancer, neoplastic cells increase the expression of magnesium transport channels, which raises the intracellular concentration of the mineral, contributing to tumor growth through its function of increasing energy demand. The data obtained in this review illustrates the influence of magnesium on the progression of breast cancer. However, the existing data are scarce and inconsistent, which demonstrates a need for further studies on the subject with a goal to have better control of the disease.

?? Does this indicate increased Magnesium would INCREASE the growth of Breast Cancer??

Tags: Breast Cancer Magnesium