Long-term depression reduced by half after stopping ultra-processed foods for just 4 weeks

Reducing Ultra-processed Foods From the Diets of Patients With Depression - A Pilot Crossover Trial

JAMA Psychiatry Sept, 2026 doi:10.1001/jamapsychiatry.2026.2320 PDF behind paywall

D. Nyasha Chagwedera, MD, PhD1; Eliana Kim, MD2; Dorothy T. Chiu, PhD3 et al

  • 19 participants
  • Clinician-rated depression scores averaged 8.1 during the low-UPF period versus 18.9 during the usual-diet period on a scale from 0 to 60, where higher scores indicate worse symptoms.
  • Anxiety scores were also lower during the dietary intervention, averaging 4.6 versus 7.4 during the usual diet on a scale from 0 to 21.

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18,000 studies on UPF association with Depression in Google Scholar as of Nov 2026

  • Ultra-Processed Food Is Positively Associated With Depressive Symptoms Among United States Adults Dec 2020 PDF
  • Relationship between 39 dietary markers of ultra-processed food and incident depression: evidence from the prospective UK Biobank cohort study - August 2026 PDF