Kidney failure 1.1 X more likely if poor Vitamin D Receptor – meta-analysis

Association of vitamin D receptor TaqI and ApaI genetic polymorphisms with nephrolithiasis and end stage renal disease: a meta-analysis.

BMC Med Genet. 2019 Dec 10;20(1):193. doi: 10.1186/s12881-019-0932-6.

Hussain T1, Naushad SM2, Ahmed A3, Alamery S3,4, Mohammed AA3, Abdelkader MO4, Alkhrm NAN4.

* Chronic Kidney Disease (stage 3) slowed by 30 ng of Vitamin D and Calcitriol – Dec 2019 * 1 in 10 have Chronic Kidney Disease – review Sept 2019 * Just 2 doses of Vitamin D resulted in many benefits (Chronic Kidney Disease)– Jan 2018 * More than 30 ng of vitamin D is sometimes needed (Kidney needs 50 ng) – March 2019 The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019 Omega-3, Magnesium, Zinc. Quercetin, non-daily Vit D. Curcumin, intense exercise, Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators 1. # Items in both categories Kidney and Vitamin D Receptor are listed here: {category} --- Kidney category starts with {include} Overview Kidney and vitamin D contains the following summary {include}

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BACKGROUND:

The deficiency of vitamin D receptor (VDR) or its ligand, vitamin D3, is linked to the development of renal diseases. The TaqI (rs731236) and ApaI (rs7975232) polymorphisms of VDR gene are widely studied for their association with renal disease risk. However, studies have largely been ambiguous.

METHODS:

Meta-analysis was carried out to clarify the association of TaqI (2777 cases and 3522 controls) and ApaI (2440 cases and 3279 controls) polymorphisms with nephrolithiasis (NL), diabetic nephropathy (DN) and end stage renal disease (ESRD).

RESULTS:

The VDR TaqI C-allele under allele contrast was significantly associated with ESRD in both fixed effect and random effect models, and ApaI C-allele with ESRD only under fixed effect model. Cochrane Q-test showed no evidence of heterogeneity for TaqI polymorphism and a significant heterogeneity for Apa I polymorphism. No publication bias was observed for both the polymorphisms.

CONCLUSIONS:

The present meta-analysis identifies TaqI and ApaI polymorphisms of VDR gene as risk factors for renal diseases.