How active vitamin D (Calcitriol) deals with cancer

Created June 2015

Mechanistic Effects of Calcitriol in Cancer Biology.

Nutrients. 2015 Jun 19;7(6):5020-5050.

Díaz L1, Díaz-Muñoz M2, García-Gaytán AC3, Méndez I4.

1Departamento de Biología de la Reproducción, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga No. 15, Tlalpan, Mexico City 14000, Mexico. lorenzadiaz@gmail.com.

2Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM), Campus UNAM-Juriquilla, Blvd. Juriquilla 3001, Querétaro 76230, Mexico. mdiaz@comunidad.unam.mx.

3Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM), Campus UNAM-Juriquilla, Blvd. Juriquilla 3001, Querétaro 76230, Mexico. acgarciag02@gmail.com.

4Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM), Campus UNAM-Juriquilla, Blvd. Juriquilla 3001, Querétaro 76230, Mexico. isabelcm@unam.mx.

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Besides its classical biological effects on calcium and phosphorus homeostasis, calcitriol, the active vitamin D metabolite, has a broad variety of actions including anticancer effects that are mediated either transcriptionally and/or via non-genomic pathways.

In the context of cancer, calcitriol

  • regulates the cell cycle,

  • induces apoptosis,

  • promotes cell differentiation and

  • acts as anti-inflammatory factor within the tumor microenvironment.

In this review, we address the different mechanisms of action involved in the antineoplastic effects of calcitriol.

PMID: 26102214

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Tags: Calcitriol Cancer