HIV treatment augmented by high-dose vitamin D, daily or weekly

Potential immune modulatory effect of vitamin D in HIV infection: A review

https://doi.org/10.1016/j.clnesp.2021.12.005

Raiha Qurban a, Sharmeen Saeed a, Wajiha Kanwal a, Kashaf Junaid b, Abdul Rehman a rehman.mmg@pu.edu.pk

a Department of Microbiology and Molecular Genetics, University of the Punjab, Lahore-54590, Pakistan

b College of Applied Medical Sciences, Jouf University, Sakaka, Al Jouf, Saudi Arabia

Vitamin D is a fat soluble hormone that is majorly involved in the classical function of calcium and phosphorus hemostasis and bone mineralization as well non classical functions of immune modulation in various viral and autoimmune diseases. Both innate and adaptive immunity is aided by vitamin D. Deficiency of vitamin D is not only linked with bone and muscle disorders but it has a critical role in many infectious and noninfectious diseases. A growing body of literature suggests vitamin D deficiency in human immunodeficiency virus (HIV) infected patients. HIV affects 36.7 million people worldwide. Currently a valuation of 0.13 million people are infected with acquired immunodeficiency syndrome (AIDS) in Pakistan. Various studies showed that hypovitaminosis D may aggravate the disease severity in HIV patients by compromising the immune system. Calcidiol supplementation is credibly a promising adjuvant of combination anti-retroviral therapy (cART) for the treatment of HIV by increasing CD4 T-cells and lowering the viral load. This review accentuates vitamin D's functions as an immune modulator in HIV, the effect of hypovitaminosis D in diseases severity, and its supplementation impact on the treatment of HIV infected patients.

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