Higher vitamin D is associated with higher Folate or higher Vitamin B-12

Created July 2020

Plasma 25-hydroxyvitamin D Is Positively Associated With Folate and Vitamin B 12 Levels in Adolescents

Nutr Res. 2020 Jun 6;79:87-99. doi: 10.1016/j.nutres.2020.06.003

Abdur Rahman 1, Abdullah Al-Taiar 2, Lemia Shaban 3, Reem Al-Sabah 4, Olusegun Mojiminiyi 5

Note: Many doctors prescribing high doses of Vitamin D also prescribe Vitamin B-12 * 5X difference in B-12 bioavailability (emulsion best) * Tested German pregnancies for 27 deficiencies, B-12 deficiency was found most frequently - June 2018 * 3 out of 4 Vegans are deficient, 1 out of 4 elderly 1. Vitamin B12 in VitaminDWikiincludes the following {include} --- * Vitamin D and Folate fortification of foods - April 2012 * Vitamin D is 100X better than folic acid during pregnancy * Dr. Coimbra interview covering Vitamin D, Magnesium, Folate, Vaccines - Oct 2018 in Portuguese * Off topic: Folic Acid - the horror story (for a small percentage of people) - Sept 2013 * Note: Folic Acid is not Folate

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Higher Vitamin D is 35% more likely if higher Vitamin B12

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Vitamin D affects the absorption of folate in vitro, and perhaps of vitamin B12 (B12). However, epidemiological studies on the association of vitamin D with folate and B12 are inconclusive. We hypothesized a positive association of plasma 25-hydroxyvitamin D [25(OH)D] with folate and B12 levels in adolescents. This hypothesis was tested in a cross-sectional study of healthy adolescents (11-16 years old; n = 1416), selected from public middle schools from across Kuwait, using stratified multistage cluster random sampling. Plasma 25(OH)D was measured by LC-MS/MS. Serum B12 and total folate in hemolyzed whole blood were analyzed with commercial kits; RBC and plasma folate were calculated from total folate. Data on potential confounders were collected from the parents and adolescents. In a univariable model, 25(OH)D as a continuous variable was positively associated with each of total, RBC, and plasma folate (P < .001). After adjusting for potential confounders, this association remained significant with total folate (β = 2.0, P < .001) and red blood cell folate (β = 1.8, P < .001), but not with plasma folate (β = 0.2, P = .34). A similar pattern of association was evident when 25(OH)D was fitted as categorical variable. Correlation between B12 and 25(OH)D was weak but significant (ρ = 0.1, P < .001). 25(OH)D was positively associated with B12 in both univariable and multivariable models (P < .001) when fitted as a categorical variable only. Simultaneous quantile regression confirmed these results.

We conclude that plasma 25(OH)D is positively associated with folate and B12 levels in adolescents. Properly designed large-scale randomized controlled trials are warranted to investigate the causal role of vitamin D in folate and B12 absorption.

Tags: B12