High Blood Pressure reduced by Vitamin D supplementation in seniors and obese – meta-analysis

Created May 2019

The effect of vitamin D3 on blood pressure in people with vitamin D deficiency: A system review and meta-analysis.

Medicine (Baltimore). 2019 May;98(19):e15284. doi: 10.1097/MD.0000000000015284.

He S, Hao X.

* Blood pressure reduced by monthly 100,000 IU of vitamin D in those who were deficient – RCT Oct 2017 * Hypertension risk decreased 10X by increasing vitamin D levels to more than 40 ng – Nov 2017 This study does not appeared to have considered diabetics * Vitamin D reduced only the systolic blood pressure in T2DM – Meta-analysis April 2019 * Blood pressure in diabetics reduced by 12 weekly doses of 50,000 IU vitamin D – RCT Jan 2014 * Pre-diabetes and hypertension 2.4X more common when less than 30 ng of vitamin D – Jan 2011 This study does not appeared to have considered hypertension and strokes * Vascular dementia (after strokes) 32X more likely in Hypertensives with low vitamin D – Oct 2015 * Stroke is 13.5 X more likely if low vitamin D and high blood pressure – March 2015 This study does not appeared to have considered hypertension during pregnancies * Preeclampsia risk reduced 7X by 4,000 IU of Vitamin D daily – RCT March 2018 Wonder if the meta-analysis on this page failed to consider the dose size (a common oversight) * Hypertension not reduced much if use less than 5,000 IU of Vitamin D – meta-analysis June 2018 --- 1. Hypertension category listing contains the following {include} --- 1. # Items in both categories Hypertension and Meta-analyses are listed here: {category}

OBJECTIVE:

To evaluate the effect of vitamin D3 on blood pressure in people with vitamin D deficiency.

METHODS:

Randomized controlled trials (RCTs) were electronically searched databases including CNKI, VIP, WanFang Data, the Cochrane Library, PubMed, and EMbase which were about oral vitamin D3 among people with vitamin D deficiency from inception to December 2017. Two reviewers independently screened literature according to the inclusion and extracted data; meta-analysis was performed using RevMan5.3.

RESULTS:

A total of 17 RCTs with 22 arms involving 1687 participants were included. The results of meta-analysis showed that, there were no significant differences between the vitamin D deficiency group and the control group on the level of change in systolic pressure (ΔSBP) [weighted mean difference (WMD) = -1.94, 95% confidence interval (CI) (-3.93,0.04) P = .06] and on the level of change in diastolic pressure (ΔDBP) [WMD = -0.50, 95% CI (-1.17, 0.17) P = .14]. The results of subgroups showed that, there were statistically significant differences in the age of >50 years subgroup on ΔSBP [WMD = -2.32, 95% CI (-4.39, -0.25) P = .03]; there were statistically significant differences in the hypertension subgroup on ΔSBP [WMD = -6.58, 95% CI (-8.72, -4.44) P <.00001]; there were statistically significant differences in the hypertension subgroup on ΔDBP [WMD = -3.07, 95% CI (-4.66, -1.48) P = .0002]; there were statistically significant differences in the body mass index (BMI) >30 subgroup on ΔSBP [WMD = -3.51, 95% CI (-5.96, -1.07) P = .005].

CONCLUSION:

Oral vitamin D3 has no significant effect on blood pressure in people with vitamin D deficiency. It reduces systolic blood pressure in people with vitamin D deficiency that was older than 50 years old or obese . It reduces systolic blood pressure and diastolic pressure in people with both vitamin D deficiency and hypertension.

Tags: Hypertension Meta-analysis