Exercise reduces cancer deaths, Magnesium RDA reduces deaths even more

Physical activity, dietary calcium to magnesium intake, and mortality in the National Health and Examination Survey 1999–2006 cohort

International Journal of Cancer https://doi.org/10.1002/ijc.32634

Elizabeth A. Hibler PhD, MPH Xiangzhu Zhu MD, MPH Martha J. Shrubsole PhD Lifang Hou MD, PhD Qi Dai MD, PhD

Death rates for 20,000 people, 2,600 deaths (smaller is better) | | | | | --- | --- | --- | | | Cancer Deaths | CVD Deaths | | High Exercise and < RDA Magnesium | 0.6 | 0.38 | | High Exercise and RDA level of Magnesium | 0.47 | 0.40 | * Death after Breast Cancer 2 times less likely if take lots of Magnesium – Dec 2015 * Colon cancer 25 percent less likely if consume Calcium, Magnesium, Zinc, etc.– Nov 2018 * Pancreatic Cancer risk increased 24 percent for every 100 mg less of Magnesium intake – Dec 2015 * Muscle pain (Low Magnesium) plus Low Vitamin D associated with 10X more Cancer, etc (San Francisco) – Aug 2017 * Breast cancer associated with high Calcium AND low vitamin D - April 2015 * Unhealthy Calcium to Magnesium ratio Note: Increasing Magnesium increases both Vitamin D in blood and in tissues click on chart for details Magnesium is vital to Vitamin D in 4 places (maybe 8) – March 2018 1. Magnesium and Vitamin D contains the following summary {include} Overview Magnesium and vitamin D Has a venn diagram of relationship of Mg and Vit D {include}

📄 Download the PDF from VitaminDWiki

Calcium and magnesium affect muscle mass and function. Magnesium and calcium are also important for optimal vitamin D status. Vitamin D status modifies the associations between physical activity and risk of incident cardiovascular disease (CVD) and CVD mortality. However, no study examined whether levels of magnesium and calcium and the ratio of dietary calcium to magnesium (Ca:Mg) intake modify the relationship between physical activity and mortality. We included 20,295 National Health and Nutrition Examination Survey participants (1999–2006) aged >20 years with complete dietary, physical activity, and mortality data (2,663 deaths). We assessed physical activity based on public health guidelines and sex‐specific tertiles of MET‐minutes/week. We used Cox proportional hazards models adjusted for potential confounding factors and stratified by the intakes of magnesium, calcium, Ca:Mg ratio.

We found higher physical activity was significantly associated with reduced risk of total mortality and cause‐specific mortality, regardless of Ca:Mg ratio, magnesium or calcium intake. In contrast, both moderate and high physical activity were significantly associated with substantially reduced risks of mortality due to cancer when magnesium intake was above the RDA level. We also found higher physical activity was significantly associated with a reduced risk of mortality due to cancer only when Ca:Mg ratios were between 1.7–2.6, although the interaction was not significant. Overall, dietary magnesium and, potentially, the Ca:Mg ratio modify the relationship between physical activity and cause‐specific mortality. Further study is important to understand the modifying effects of the balance between calcium and magnesium intake on physical activity for chronic disease prevention.