Epigenetics - PDFs and links, with and without Vitamin D

Created October 2019

Human Epigenetics: How Science Works - PDF of 2019 book

New textbook explains human epigenetics to undergraduates

Carlberg, Carsten, Molnár, Ferdinand, DOI 10.1007/978-3-030-22907-8

Chromatin

DNA Methylation

Histone Modifications|

Chromatin Modifying Proteins and RNAs

Embryogenesis and Cellular Differentiation

Population Epigenetics and Aging

Cancer Epigenetics

Neuroepigenetics

Nutritional Epigenetics

Epigenetics of Immune Function

Epigenome-Environment Interactions and Their Therapy

📄 Download the PDF from Sci-Hub via VitaminDWiki

Strangely, "Vitamin D" is not mentioned in his book even once

A few images from the book

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A few of Carlberg, Carsten Vitamin D Studies

VitaminDWiki pages with EPIGENETICS in title (15 as of Dec 2021)

This list is automatically updated

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Vitamin D: a Review of its Effects on Epigenetics and Gene Regulation – 2020

Folia Med (Plovdiv) . 2020 Dec 31;62(4):662-667. doi: 10.3897/folmed.62.e50204..

Violeta Snegarova 1, Darina Naydenova 2

Vitamin D is a secosteroid hormone with known beneficial effects on several body systems other than the musculoskeletal system. Both 25 dihydroxy vitamin D [25(OH)2D] and its active hormonal form, 1,25-dihydroxyvitamin D [1,25(OH)2D] are essential for hu-man physiological functions, including damping down inflammation and the excessive intracellular oxidative stresses. In the present study we set out to review all available literature on vitamin D and the role it plays in epigenetics and gene regulation. We searched the PubMed/Medline electronic database for studies published in the English language up to January 2020. The Medical Subject Headings (MeSH) database was searched with the keywords 'vitamin D', 'DNA methylation', 'nutritional supplements', 'epigenome' and 'pregnancy'. Observational studies, supplementation studies, and meta-analyses dealing with the effect of vitamin D on epigenetics and gene regula-tion were included in the review. The obtained information from the databases such as PubMed, Google Scholar, and ResearchGate was analysed and summarized.

We found that hypovitaminosis D increases the incidence and severity of several age-related common diseases such as the oxidative stress-associated metabolic disorders.

These include

  • obesity,

  • insulin resistance,

  • type 2 diabetes,

  • hypertension,

  • pregnancy complications,

  • memory disorders,

  • osteoporosis,

  • autoimmune diseases,

  • certain cancers, and

  • systemic inflammatory diseases.

New understandings of vitamin D-related advances in metabolomics, transcriptomics, epigenetics, in relation to its ability to control oxidative stress in conjunction with micronutrients, vitamins, and antioxidants, following normalization of serum 25(OH)D and tissue 1,25(OH)2D concentra-tions, are likely to promise better cost-effective clinical outcomes in humans. There is a strong reciprocity between the vitamin D system and epigenetic mechanisms. The vitamin D system is, on the one hand regulated by epigenetic mechanisms and, on the other hand, is involved in regulating epigenetic events.

📄 Download the PDF from VitaminDWiki

Restoring Vitamin D levels restored ~2 years to epigenetic life indictors - Dec 2021

People who had low vitamin D and supplemented so as to get >20 ng of vitamin D restored ther epigenitic indictors by ~1 years = same as the level of those who initially has > 20 ng of vitamin D. Study does not indicate Vitamin D dose size.

📄 Download the PDF preprint from VitaminDWiki

Some Epigenetic and Vitamin D items on the web - Dec 2019

Tags: Genetics