Depression in adolescent girls reduced somewhat by 50,000 IU weekly for 9 weeks

Created August 2017

High Dose Vitamin D Supplementation Is Associated With a Reduction in Depression Score Among Adolescent Girls: A Nine-Week Follow-Up Study.

J Diet Suppl. 2017 Jul 31:1-10. doi: 10.1080/19390211.2017.1334736. [Epub ahead of print]

1. Depression has been found to be independently reduced by Vit D, Magnesium, Omega-3, and St. John's Wort in a variety of studies Search Google for depression (gut OR digestion) 23,800,000 hits as of Sept 2017 * Example 1 Depression linked with bad digestion * Example 2 Where There Is Mental Illness, There Is Poor Digestion * It is likely that many of the depressed girls had poor guts and thus poor response to vitamin D. * * *This study probably would have been much more successful if it had used a gut-friendly form of Vitamin D, for longer than 9 weeks, along with some combination of Magnesium, Omega-3, and St. John's wart* * Vitamin D * * Depression category listing has items along with related searches** * Anti-depression medication about as good as big increase in vitamin D – meta-analysis of flawless data April 2014 * Much less depression if higher than 43 ng of vitamin D – Oct 2012 * Just 1500 IU of Vitamin D significantly helps Prozac – RCT March 2013 * Senior Depression and Vitamin D – review March 2016 Magnesium * Depression is associated with low Magnesium – meta-analysis April 2015 * Depression greatly reduced by taking 250 mg of Magnesium Chloride daily for 6 weeks– RCT June 2017 Omega-3 * How Omega-3 Fights Depression – LEF July 2016 * Depression treated somewhat by Omega-3 (St. John's Wort better) – RAND org reviews 2015 * Depression substantially decreased with Omega-3 – Sept 2015 * Note: Increasing Omega-3 increases the amount of vitamin D getting to the cells Items in both categories Depression and Intervention: {category}

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Subset of Table 4. Effects of vitamin D on depression scores.

**
	Before	After	p value
Mild depression	16	15	.002
Moderate depression	23	20	.001
Severe depression	33	26	.001
25 (OH) vitamin D	6.7 ng	35 ng	.001	**

Bahrami A1,2, Mazloum SR3, Maghsoudi S4, Soleimani D5, Khayyatzadeh SS5, Arekhi S2, Arya A2, Mirmoosavi SJ6,7, Ferns GA8, Bahrami-Taghanaki H7, Ghayour-Mobarhan M9.

Although vitamin D deficiency is known to be a risk factor for some psychological disorders, there have been few studies on the effects of vitamin D supplementation on their symptoms. Depression and aggression are common mental disorders and are associated with disability and disease burden. We aimed to evaluate the effectiveness of high-dose vitamin D supplementation on depression and aggression scores in adolescent girls. Nine hundred forty adolescent girls received vitamin D3 at a dose of 50,000 IU/week for 9 weeks. Anthropometric parameters and blood pressure were measured using standard protocols at the baseline and at the end of the study. Depression score was evaluated using the Beck Depression Inventory-II and aggression was evaluated using the Buss-Perry Aggression Questionnaire at baseline and at the end of the study. Comparison among the four categories of depression score (normal, mild, moderate, and severe) revealed no significant differences in demographic and anthropometric parameters at baseline. After 9 weeks of vitamin D supplementation, there was a significant reduction on mild, moderate, and severe depression score. However, vitamin D supplementation had no significant effect on aggression score. Our results suggest that supplementation with vitamin D may improve depressive symptoms among adolescent girls, as assessed by questionnaire, but not aggression score. Formal, larger, randomized controlled studies are required to confirm this effect on cases with different degrees of depression.

PMID: 28759290 DOI: 10.1080/19390211.2017.1334736

Tags: Depression Intervention Intervention - non daily