COVID test positive is about half as likely if have Vitamin D – 24th meta-analysis

COVID-19 and Vitamin D (Co-VIVID Study): a systematic review and meta-analysis of randomized controlled trials

Expert Rev Anti Infect Ther 2022 Jan 27. doi: 10.1080/14787210.2022.2035217

Seshadri Reddy Varikasuvu 1, Balachandar Thangappazham 2, Alekya Vykunta 3, Pragathi Duggina 4, Munikumar Manne 5, Hemanth Raj 6, Sowjanya Aloori 7 INDIA

Introduction: Vitamin D levels have been reported to be associated with COVID-19 susceptibility, severity and mortality events. We performed a meta-analysis of randomized controlled trials (RCTs) to evaluate the use of vitamin D intervention on COVID-19 outcomes.

Areas covered: Literature search was conducted using PubMed, Cochrane library, and ClinicalTrials.gov databases. We included RCTs reporting the use of vitamin D intervention to control/placebo group in COVID-19. The study was registered at PROSPERO: CRD42021271461.

Expert opinion: A total of 6 RCTs with 551 COVID-19 patients were included. The overall collective evidence pooling all the outcomes across all RCTs indicated the beneficial use of vitamin D intervention in COVID-19 (relative risk, RR = 0.60, 95% CI 0.40 to 0.92, Z=2.33, p=0.02, I2 = 48%).

The rates of RT-CR positivity was significantly decreased in the intervention group as compared to the non-vitamin D groups (RR = 0.46, 95% CI 0.24 to 0.89, Z=2.31, p=0.02, I2 = 0%). Conclusively, COVID-19 patients supplemented with vitamin D are more likely to demonstrate fewer rates of ICU admission, mortality events and RT-PCR positivity.

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