COVID-19 treated by Vitamin D (reduce ICU by 3X) - 22nd meta-analysis

The effect of vitamin D supplementation on mortality and Intensive Care Unit admission of COVID-19 patients. A systematic review, meta-analysis and meta-regression

Diabetes Metab Res Rev. 2021 Dec 29;e3517. doi: 10.1002/dmrr.3517

Nikolaos Tentolouris 1, Georgia Samakidou 1, Ioanna Eleftheriadou 1, Anastasios Tentolouris 1, Edward B Jude 2 Greece

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Aims: The aim of this systematic review and meta-analysis was to investigate the effect of vitamin D supplementation on mortality and admission to intensive care unit (ICU) of COVID-19 patients.

Methods: A systematic search of PubMed, Google Scholar, Embase, Web of Science and medRxiv with terms relative to vitamin D supplementation and COVID-19 was conducted on March, 26th , 2021 . Comprehensive Meta-Analysis software was used for the quantitative assessment of data and random-effects model was applied. To investigate the association between the dose of vitamin D and the outcomes of interest, meta-regression analysis was performed.

Results: 2,078 patients from 9 studies with data on mortality were included (583 received vitamin D supplementation, while 1,495 did not). 61 (10.46%) individuals in the treated group died, compared to 386 (25.81%) in the non-treated group [odds ratio (OR): 0.597; 95% CI: 0.318-1.121; p=0.109]. 860 patients from 6 studies with data on ICU admission were included (369 received vitamin D supplementation, while 491 did not).

45 (12.19%) individuals in the treated group were admitted to ICU, compared to 129 (26.27%) in the non-treated group (OR: 0.326 ; 95%CI: 0.149-0.712; p=0.005). No significant linear relationship between vitamin D dose and log OR of mortality or log OR of ICU admission was observed.

Conclusion: This meta-analysis indicates a beneficial role of vitamin D supplementation on ICU admission, but not on mortality, of COVID-19 patients. Further research is urgently needed to understand the benefit of vitamin D in Covid-19.

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VitaminDWiki VIRUS category with ICU in title

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VitaminDWiki - Meta-analysis of VIRUS

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