Colorectal Cancer Patients 2.4 X more likely to have poor Vitamin D receptors (less D to cells)

Created May 2020

Decreased Vitamin D Receptor Protein Expression Is Associated With Progression and Poor Prognosis of Colorectal Cancer Patients

Int J Clin Exp Pathol, 2020 Apr 1;13(4):746-755. eCollection 2020. PMID: 32355523

Qi Shi 1, Xue-Ping Han 1, Jie Yu 2, Hao Peng 1, Yun-Zhao Chen 2, Feng Li 1 3, Xiao-Bin Cui 1

Note: to believe that a measurement is not ddue to chance it must have a P <0.05 This measurement has a P = 0.0000000000000000005 1. Note: Several Cancers have "learned" how to protect themselves from Vitamin D After the cancer starts, it decreases the Vitamin D Receptor activation.     Thus for some cancers: Cancer ==> poor VDR, rather than poor VDR ==> Cancer * Omega-3,  Magnesium, Zinc,  Quercetin,  non-daily Vit D,  Curcumin, intense exercise,   Ginger,   Essential oils, etc** Note: The founder of VitaminDWiki, who has a poor VDR, uses 10 of the 12 known VDR activators --- 1. Vitamin D Receptor and Cancers {include}

This study aimed to investigate vitamin D receptor (VDR) expression levels and evaluate their clinical significance in patients with colorectal cancer (CRC). VDR protein expression was validated by immunohistochemistry in 188 CRC tissues and 134 normal colorectal tissues. The associations between VDR expression and clinicopathologic characteristics, including prognostic outcomes, were analyzed. VDR expression in normal colorectal tissue was higher than that in CRC ( 83.6% versus 34.6%, P = 4.489 × 10-20 ) and generated moderate diagnostic performance for CRC detection (AUC = 0.88, sensitivity = 0.87, specificity = 0.84). Low VDR expression was associated with invasion depth (P = 0.001) and poor survival in CRC (P = 0.031). Univariate Cox analysis demonstrated VDR expression (P = 0.036) was a significant prognostic predictor for survival in patients with CRC. Low VDR expression could be a valuable diagnostic and prognostic biomarker for CRC patients. Targeting VDR may offer a potential therapeutic strategy for blocking CRC.

Tags: Colon Cancer Vit D Receptor