Chronic kidney treatment by Vitamin D lacks consensus: type, how much

Created October 2018

Native vitamin D in pre-dialysis chronic kidney disease.

Nefrologia. 2018 Sep 28. pii: S0211-6995(18)30123-1. doi: 10.1016/j.nefro.2018.07.004

* Hypothesis: Magnesium might prevent and treat Chronic Kidney Disease – April 2018 * Dialysis patients 23 percent more likely to live if had just 10 ng more Vitamin D – meta-analysis Feb 2018 * UV is one of the ways to increase Vitamin D levels, even with poor kidney – Jan 2018 * Standard oral vitamin D is not a good way to supplement if have Chronic Kidney Disease – March 2016 Promising other methods include: UV, topical, gut-friendly, injection, inhaled, sublingual, spray --- 1. Kidney category starts with {include} --- 1. Overview Kidney and vitamin D contains the following summary {include}

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Cardoso MP1, Pereira LAL2.

  • 1 Faculty of Medicine of University of Porto, Al. Prof. Hernâni Monteiro, 4200-451 Porto, Portugal. Electronic address: mariana.pinto.cardoso@gmail.com.

  • 2 Institute of Investigation and Innovation in Health, University of Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal; Nephrology and Infeciology Group, INEB-National Institute of Biomedical Engineer, University of Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal; Department of Nephrology, São João Hospital Center, Al. Prof. Hernâni Monteiro, 4200-451 Porto, Portugal.

Chronic kidney disease patients have a high prevalence of vitamin D insufficiency/deficiency. Vitamin D deficiency has been associated with a variety of bone, metabolic and cardiovascular disorders. However, the role of native vitamin D supplementation (ergocalciferol, cholecalciferol or calcifediol) remains unclear in chronic kidney disease (CKD), particularly in the pre-dialytic phase. Several international guidelines have been developed on CKD-Mineral and Bone Disorder, but the optimal strategy for native vitamin D supplementation and its clinical benefit remains a subject of debate in the scientific community. This paper aims to review the available literature, including randomized clinical trials that evaluated the effects of native vitamin D supplementation on pre-dialysis CKD on biochemical and clinically relevant outcomes.

Tags: Kidney