Children helped by 2,000 IU of vitamin D, but not RDA amount (600 IU) – RCT

Created October 2017

Impact of Three Doses of Vitamin D3 on Serum 25(OH)D Deficiency and Insufficiency in At-Risk Schoolchildren

The Journal of Clinical Endocrinology & Metabolism, jc.2017-01179, Published: 27 Sept 2017, https://doi.org/10.1210/jc.2017-01179

Jennifer M Sacheck, Ph.D. Maria I Van Rompay, Ph.D. Virginia R Chomitz, Ph.D. Christina D Economos, Ph.D. Misha Eliasziw, Ph.D. Elizabeth Goodman, M.D. Catherine M Gordon, M.D. Michael F Holick , Ph.D., M.D.

However, only 60% got > 30 ng in 3 months     (>30 ng is considered sufficient by many organizations and countries) * * Infant-Child category listing has items along with related searches** * Children getting 60,000 IU monthly got to vitamin D level of 33 ng – Sept 2015 * Note: 60,000 IU monthly is approximately 2,000 IU daily. * Thus 50% got > 33 ng in 2015, which is very similar to 60% > 30 ng in the subsequent study * How you might double your response to vitamin D *   Use different form, add Magnesium, add Omega-3, take with largest meal of the day, stop drinking cola soft drinks, etc. 20 Most-visited pages in Infant-Child category in VitaminDWiki {LISTPAGES}

Objective

We investigated the daily dose of vitamin D needed to achieve serum 25-hydroxyvitamin D [25(OH)D] sufficiency among schoolchildren at-risk for deficiency.

Study Design

The Daily D Health Study was a randomized double-blind vitamin D supplementation trial among racially/ethnically diverse schoolchildren (n=685) in the northeastern U.S. Children were supplemented with vitamin D3 at 600, 1000, or 2000 IU/day for six months. Measurements included serum 25(OH)D at baseline (Oct-Dec), 3 months (Jan-March), 6 months (April-June), and 12 months (6 months post-supplementation).

Results

At baseline, mean ± SD serum 25(OH)D was 22.0 ± 6.8 ng/mL; with

  • 5.5% severely vitamin D deficient (<12 ng/mL),

  • 34.1% deficient (12-19 ng/mL), 4

  • 9.0% insufficient (20-29 ng/ml), and

  • 11.4% sufficient (≥30 ng/mL).

The lowest levels of serum 25(OH)D were found among black (17.9 ± 6.7 ng/mL) and Asian children (18.9 ± 4.8 ng/mL), with no baseline differences by weight status. Serum 25(OH)D increased over 6 months in all three dose groups. The 2000 IU group achieved higher mean serum 25(OH)D than the other two dose groups (33.1 versus 26.3 and 27.5 ng/mL; p<0.001), with 59.9% of this group attaining sufficiency at 3 months and only 5.3% remaining severely deficient/deficient at 6 months. All dose groups demonstrated a fall in 25(OH)D at 12 months.

Conclusions

Children who are at risk for vitamin D deficiency benefit from daily sustained supplementation of 2000 IU/day compared to lower doses closer to the current RDA for vitamin D intake. This benefit occurred over the winter months when serum 25(OH)D levels tend to fall.

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Tags: Infant-Child