Cervical Cancer is prevented by Vitamin D, and treated if caught early (genes are important)

The Preventive Role of the Vitamin D Endocrine System in Cervical Cancer

Int J Mol Sci. 2023 May 12;24(10):8665. doi: 10.3390/ijms24108665.

Euclides Avila 1, Bryan Javier Noriega-Mejía 1, Jocelyn González-Macías 1, Ulises Cortes-Hernández 1, Janice García-Quiroz 1, Rocío García-Becerra 2, Lorenza Díaz 1

Vitamin D along with its active metabolite calcitriol and its metabolic and signaling system, known as the vitamin D endocrine system, have been widely recognized as a pivotal regulator of calcium homeostasis in addition to non-calcemic antitumoral effects in a variety of human cancers, including cervical cancer. Several studies have found an inverse relationship between the incidence of cervical neoplasia and vitamin D levels.

This narrative review updates the current evidence supporting the notion that the vitamin D endocrine system has a preventive role on cervical cancer, mainly in the early phases of the disease, acting at the level of

• suppressing cell proliferation,

• promoting apoptosis,

• modulating inflammatory responses, and

• probably favoring the clearance of human papillomavirus-dependent cervical lesions.

Although an optimal vitamin D status helps in the prevention and regression of low-grade squamous intraepithelial lesions of the cervix, it appears that vitamin D alone or combined with chemotherapeutic agents has little effectivity once advanced cervical cancer is established. These observations suggest that an optimal vitamin D status might exert beneficial actions in the early phases of cervical cancer by preventing its onset and progression.

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4+ VitaminDWiki pages with CERVICAL in title

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VitaminDWiki - Genetics chart shows the vitamin D genes

80+ VitaminDWiki Vitamin D Receptor pages with CANCER in the title

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