Bone density improved with resveratrol (which improves Vitamin D Receptor) – RCT

Created September 2018

Effects of resveratrol on bone health in type 2 diabetic patients. A double-blind randomized-controlled trial.

Nutr Diabetes. 2018 Sep 20;8(1):51. doi: 10.1038/s41387-018-0059-4.

Bo S1, Gambino R2, Ponzo V2, Cioffi I3, Goitre I2, Evangelista A4, Ciccone G4, Cassader M2, Procopio M2.

1 Department of Medical Sciences, University of Turin, Turin, Italy. simona.bo@unito.it.

2 Department of Medical Sciences, University of Turin, Turin, Italy.

3 Department of Clinical Medicine and Surgery, Federico II University Hospital, Naples, Italy.

4 Unit of Clinical Epidemiology, CPO, "Città della Salute e della Scienza" Hospital of Turin, Turin, Italy.

* The Vitamin D Receptor can restrict how much of the Vitamin D in the blood actually gets to cells, such as bone cells. * Resveratrol is one of 7 ways to negate the Vitamin D Receptor restrictions * This study found that increasing Resveratrol stopped bone loss * Probably by getting more Vitamin D to the bone cells Opinion: BMD would have been improved even more if the elements known to be needed for building bones were also added: Vitamin D, Magnesium, Vitamin K2, Boron, Silica, Exercise --- * Adding just vitamin D again failed to add bone density (also need Magnesium, Vitamin K, etc) – RCT Aug 2018 * Healthy bones need: Calcium, Vitamin D, Magnesium, Silicon, Vitamin K, and Boron – 2012 * Better bones again associated with higher vitamin K intake – Nov 2015 * Strong bones need both physical activity and vitamin D – Jan 2013 * Bone formation in the lab is aided by Vitamin D, Vitamin K1, and Vitamin K2 – meta-analysis Nov 2017 * Vitamin D and fractures – 24 meta-analyses and counting – Dec 2014 * * Bone - Health category listing has items along with related searches** * Resveratrol improves health (Vitamin D receptor, etc.) - many studies --- 1. Vitamin D Receptor category has the following {include}

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OBJECTIVES:

Patients with type 2 diabetes (T2DM) are at increased fracture risk. Resveratrol has shown beneficial effects on bone health in few studies. The aim of this trial was to investigate the effects of resveratrol on bone mineral density (BMD) and on calcium metabolism biomarkers in T2DM patients.

METHODS:

In this double-blind randomized placebo-controlled trial 192 T2DM outpatients were randomized to receive resveratrol 500 mg/day (Resv500 arm), resveratrol 40 mg/day (Resv40 arm) or placebo for 6 months. BMD, bone mineral content (BMC), serum calcium, phosphorus, alkaline phosphatase, and 25-hydroxy vitamin D were measured at baseline and after 6 months.

RESULTS:

At follow-up, calcium concentrations increased in all patients, while within-group variations in alkaline phosphatase were higher in both resveratrol arms, and 25-hydroxy vitamin D increased in the Resv500 arm only, without between-group differences. Whole-body BMD significantly decreased in the placebo group, while whole-body BMC decreased in both the placebo and Resv40 arms. No significant changes in BMD and BMC values occurred in the Resv500 arm. The adjusted mean differences of change from baseline were significantly different in the Resv500 arm vs placebo for whole-body BMD (0.01 vs -0.03 g/cm2, p = 0.001), whole-body BMC (4.04 vs -58.8 g, p < 0.001), whole-body T-score (0.15 vs -0.26), and serum phosphorus (0.07 vs -0.01 µmol/L, p = 0.002). In subgroup analyses, in Resv500 treated-patients BMD values increased to higher levels in those with lower calcium and 25-hydroxy vitamin D values, and in alcohol drinkers.

CONCLUSIONS:

Supplementation with 500 mg resveratrol prevented bone density loss in patients with T2DM, in particular, in those with unfavorable conditions at baseline.