Atopies (allergy, asthma, rhinitis, etc.) variously associated with low Vitamin D and poor Vitamin D Receptor
Vitamin D receptor gene polymorphisms in atopy
Immun Inflamm Dis. 2021 Aug 3. doi: 10.1002/iid3.487
Laura Tamasauskiene 1, Ieva Golubickaite 2, Rasa Ugenskiene 2, Nikolajs Sjakste 3, Natalia Paramonova 3, Lawrence Shih-Hsin Wu 4, Lawrence Shih-Jiu-Yao Wang 5 6, Brigita Sitkauskiene 1
Background: The occurrence of allergic conditions, for example allergic asthma, rhinitis, and atopic dermatitis, is rising worldwide. These allergic conditions are associated with poor life quality. Vitamin D is proposed to be linked with increased risk and severe forms of allergic diseases.
Aims: This review article aimed to evaluate the vitamin D level role and polymorphisms of vitamin D receptor gene (VDR) in atopy.
Methods & materials: We analyzed publications that were focusing on levels of vitamin D and/or polymorphism analysis of vitamin D receptor gene in allergic asthma, rhinitis, and atopic dermatitis patients.
Results: We noticed that levels of vitamin D are extensively studied in atopy by many research groups, however, polymorphisms of vitamin D receptor gene and their link with levels of vitamin D lack comprehensive data. There is evidence that vitamin D may be associated with anti-inflammatory effects in allergic diseases. Some of VDR polymorphisms also may play a role in pathogenesis of these diseases. However, the data from different studies are controversial.
Discussion: The results of different studies are usually inconsistent, most probably due to populational bias or differences in methodology. Even though, more evidence shows a positive impact of vitamin D on the risk and outcomes of allergic diseases, especially atopic dermatitis, and asthma.
Conclusions: There is controversial data about the level of vitamin D and its role in atopy; however, more evidence shows a positive impact on the risk and outcomes of allergic diseases.
📄 Download the PDF from VitaminDWiki
VitaminDWiki: Asthma, VDR
{include}
Vitamin D Receptor is associated in over 40 autoimmune studies
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019
Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 13 known VDR activators
Asthma and low vitamin D
Asthma reduced 60 percent with vitamin D supplementation – meta-analysis 2014, 2015
Strong Vitamin D deficiency associations in Asthma patients – Nov 2014
VitaminDWiki pages with ALLERG in the title
{LIST()}
VitaminDWiki - Vitamin D Receptor pages with "ASTHMA" in title
This list is automatically updated
{LIST()}