The clues for new roles of vitamin D and vitamin D receptor in neurodegeneration

Presented by E Dursan duygugezenak@gmail.com at Scientific Workshop

"Vitamin D, in the prevention of health disparities during adult life, mediterranean experts meeting"

Held on 30-31/8/2018, in Aristotle University Research Dissemination Center (KEDEA), in Thessaloniki, Greece,.

37 minute video

A few of the presented images

VDR Alz history

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Subcellular location of VDR

Plaque and Vitamin D (arrows added by VitaminDWiki)

Hypothesis 1 and 2

📄 Download the PDF from VitaminDWiki

📊 Download the PowerPoint from VitaminDWiki

This is one of 19 videos from the workshop

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Overview Alzheimer's-Cognition and Vitamin D in VitaminDWiki has the following summary

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Items in both VitaminDWiki categories Cognition and Vitamin D Receptor are listed here:

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See also VitaminDWiki

• The risk of 40 diseases at least double with poor Vitamin D Receptor as of July 2019

• Vitamin D reduces Alzheimer’s disease in at least 11 ways – Jan 2013

• Alzheimer's disease – less risk if smarter, higher vitamin D, better genes or less coffee – Dec 2017

• Alzheimer's disease most likely will need more than monotherapy such as vitamin D – May 2013

• Poor Cognition and Alzheimer’s Disease both associated with low vitamin D – review May 2015

• Alzheimer disease 5X less likely with nonmelanoma skin cancer (lots of vitamin D) – May 2013

• Hypothesis – Alzheimer’s Disease results of hormone imbalance (vitamin D etc.) – Jan 2014

• Decrease of Alzheimer’s biomarker halted by Resveratrol (perhaps due to vitamin D) – RCT Sept 2015

  • Note: Resveratrol is also important in several other vitamin D related diseases

• Why vitamin D in Alzheimer's disease - a hypothesis – Jan 2014 very interesting

• DDT 3.8 X more prevalent with Alzheimer disease (no mention that DDT decreases vitamin D) – Jan 2014

  • See VitaminDWiki DDT and other pesticides decrease vitamin D
• Variety of evidence that Vitamin D helps the brain – July 2014 has the following chart
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Presentations

• Molecular genetics and vitamin D action E. Kassi

• Vitamin D and human reproduction D. Goulis

• Effects of Vitamin D supplements and osteoporosis treatment on musculoskeletal system A. Bargiotta

• Optimizing Vitamin D status in children with pre - school wheeze or asthma: a pilot study (OptiVit) Ch. Stefanidis

• Molecular background of Vitamin D anticancer action: Impact on hypoxia inducible transcription factors (HIFs) A. Tsakalof

• Preoperative serum Vitamin D levels in patients with breast cancer is associated with histological characteristics of the tumor G. Panagiotou

• Prevalence of Vitamin D deficiency in a Greek and a Cypriot population sample S.-E. Xyda

• The relationship between Vitamin D and MTDNA encoded genes expression M. Alaylioglu

• Association of CUBN gene variants with type 2 diabetes mellitus and Vitamin D levels in an elderly Greek Population X. Tsekmekidou

• Vitamin D and cancer W. B. Grant

• Management of vitamin D deficiency: Guidelines of the Hellenic Endocrine Society K. Kotsa, S.-N. Karras

• The clues for new roles of vitamin D and vitamin D receptor in neurodegeneration E. Dursun, D. Gezen - Ak

• Vitamin D and Pregnancy A.-M. Michailidou

• Osteoporosis Markers Among Emirati Females Based on Vitamin D

• Receptor Variants and Biomechanical Parameters F. Al. Anouti

• Regulation of Parathyroid Hormone secretion in normal subjects S. Minisola

• Quantification of 25-Hydroxyvitamind3/D2 by UHPLC-DAD with online metabolites isolation and preconcentration A. Tsakalof

• Vitamin D and cognitive function in older adults: a review of the literature N. Syrmos

• The role of Vitamin D in Atopic Dermatitis V.-E. Pappa

• Anxiety and Depression is associated with decreased Vitamin D levels in an elderly population in Northern Greece D. Drivakou

• Measurement of vitamin D metabolites - Assays Naughton

• Vitamin D and Nutrition (Food fortification - Optimizing Vitamin D status in the Mediterranean region-a global perspective) Kotzakioulafi

• Vitamin D and obesity S. Tigas

• Vitamin D supplementation in clinical practice: a practical approach T. Koufakis, E. Rapti

  • On VitaminDWiki Vitamin D dosing - weekly may be better than daily – video Aug 2018