85 year olds who were not Vitamin D deficient had and continued to have few disabilities

Created November 2020

The Association between 25-Hydroxyvitamin D Concentration and Disability Trajectories in Very Old Adults: The Newcastle 85+ Study

Nutrients 2020,12, 2742; doi:10.3390/nu12092742

Sarah Hakeem 1,2,3, Nuno Mendonca 1,2,4,5, Terry Aspray 6, , Andrew Kingston , CarmenRuiz-Martin CarolJagger John C.Mathers O/Rachel Duncan7 and Tom R.Hill 1,2' tom.hill@ncl.ac.uk

image

* Frailty and Vitamin D - many studies * 80 percent of the characteristics of frailty associated with low vitamin D – May 2013 * Frailty 9X more likely if low vitamin D – Nov 2015 * Frailty risk increases 12 percent for every 10 ng less vitamin D – meta-analysis Sept 2018 * Majority of frail hospital patients had low vitamin D, which did not change with season – 2018 1. Seniors category starts with {include}

📄 Download the PDF from VitaminDWiki

Model 4

image

Background: Low vitamin D status is common in very old adults which may have adverse consequences for muscle function, a major predictor of disability. Aims: To explore the association between 25-hydroxyvitamin D [25(OH)D] concentrations and disability trajectories in very old adults and to determine whether there is an ‘adequate' 25(OH)D concentration which might protect against a faster disability trajectory.

Methodology: A total of 775 participants from the Newcastle 85+ Study for who 25(OH)D concentration at baseline was available. Serum 25(OH)D concentrations of <25 nmol/L, 25-50 nmol/L and >50 nmol/L were used as cut-offs to define low, moderate and high vitamin D status, respectively. Disability was defined as difficulty in performing 17 activities of daily living, at baseline, after 18,36 and 60 months.

Results: A three-trajectory model was derived (low-to-mild, mild-to-moderate and moderate-to-severe). In partially adjusted models, participants with 25(OH)D concentrations <25 nmol/L were more likely to have moderate and severe disability trajectories, even after adjusting for sex, living in an institution, season, cognitive status, BMI and vitamin D supplement use. However, this association disappeared after further adjustment for physical activity. Conclusions: Vitamin D status does not appear to influence the trajectories of disability in very old adults.

Tags: Seniors