2X more Parkinson's disease if modified vitamin D receptor genes – meta-analysis

Created August 2014

Vitamin D receptor gene polymorphisms and the risk of Parkinson's disease.

Neurol Sci. 2014 Aug 29. [Epub ahead of print]

Chunlei Li (1); Huiping Qi (2); Shuqin Wei (3); Le Wang (4); Xiaoxue Fan (4); Shurong Duan (4)

Sheng Bi bisheng13224510036@163.com (4)

  1. Department of Rehabilitation, The First Affiliated Hospital, Harbin Medical University, 150001, Harbin, China

  2. Department of Neurology, The Fourth Affiliated Hospital, Harbin Medical University, 150001, Harbin, China

  3. Saint-Justine Research Center, University of Montreal, Montreal, Canada

  4. Department of Neurology, The First Affiliated Hospital, Harbin Medical University, 150001, Harbin, China

A vitamin D blood test can tell you that you have a high level of vitamin D, but the Vitamin D receptor gene modifications will reduce the efficiency of getting vitamin D to the cells. * Overview Parkinson's and Vitamin D * Vitamin D Receptor can be modulated with a new compound – Feb 2014 a possibility if you know your VDR has problems * Parkinson’s Disease – no association found with changes in Vitamin D genes – meta-analysis June 2014 this appears to conflict with the study on this page * Vitamin D level can be high, but little benefit: due to kidney, genes, low Magnesium etc. genes include the VDR * Surprise:Three different types of vitamin D can activate the vitamin D receptor – Oct 2013 * Vitamin D Receptor category has the following {include} Pages listed in BOTH the categories VDR and PD {category}

The effect of vitamin D receptor (VDR) gene polymorphisms on Parkinson's disease (PD) has recently gained interest. However, evidence on this relationship is controversial. We searched PubMed, EMBASE and the Cochrane Library database targeted all studies that evaluated VDR gene polymorphisms and PD up to April 2,014. A meta-analysis was conducted on the association between VDR ApaI, BsmI, TaqI and FokI polymorphisms and PD using (1) allelic contrast, (2) dominant, (3) recessive, and (4) additive models.

A total of five relevant studies involving PD patients (n = 1,266) and controls (n = 1,649) were included in the analysis. There was a significant association between FokI polymorphism and PD.

In the pooled allelic analysis, the

  • F allele was associated with increased risk of PD ( OR 1.41 , 95 % CI 1.14-1.75).

In the genotype analysis,

  • FF + Ff versus ff showed a significant association with PD in the dominant model ( OR 2.32 , 95 % CI 1.49-3.61, P = 0.0002).

FF versus ff showed a significant association with PD in the additive model ( OR 2.45 , 95 % CI 1.52-3.93, P = 0.0002).

There was also a statistically significant association between VDR BsmI polymorphisms in the recessive model,

  • BB versus Bb + bb showed a significant increased risk of PD ( OR 1.37 , 95 % CI 1.01-1.87, P = 0.04).

No significant associations were observed between VDR ApaI and TaqI polymorphisms and PD.

To sum up, VDR BsmI and FokI polymorphisms were associated with increased risk of PD.

PMID: 25169913

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Tags: Meta-analysis Parkinson's Vit D Receptor