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Vitamin D in Prevention and Treatment of COVID-19 (16 reasons) – Sept 1, 2020

Vitamin D in Prevention and Treatment of COVID-19: Current Perspective and Future Prospects

J Am Coll Nutr. 2020 Sep 1;1-14. doi: 10.1080/07315724.2020.1806758
Navya Vyas 1 2, Shilia Jacob Kurian 2 3, Debasis Bagchi 4, Mohan K Manu 2 5, Kavitha Saravu 2 6, Mazhuvancherry Kesavan Unnikrishnan 7, Chiranjay Mukhopadhyay 8, Mahadev Rao 3, Sonal Sekhar Miraj 2 3

VitaminDWiki

COVID-19 treated by Vitamin D - studies, reports, videos as of July 29 includes

    • 21 trials (generally treatment, not prevention), +10 observational studies,
    • +7 recommendations, +34 associations, +58 speculations, +20 videos,

and has the following recent updates

Top Vitamin D and COVID-19 recent updates

Search Google Scholar for COVID-19 Vitamin D 19,100 publications Sept 18, 2020

 Download the PDF from VitaminDWiki
Vitamin D deficiency (VDD) partly explains geographical differences in COVID-19 susceptibility, severity, and mortality. VDD among African-Americans, diabetics, hypertensive, and aged populations possibly explain the higher death rate, aggravated by cocooning. Vitamin D is pleiotropic, mediating bone metabolism, calcium homeostasis, and immune functions, whereas VDD is associated with inflammatory reactions and immune dysfunction, predisposing individuals to severe infections.
Vitamin D modulates innate and adaptive immunity via the expression of genes that code antimicrobial peptides (AMPs). And the expression of cluster of differentiation (CD)14, the co-receptor for epidermal toll-like receptor (TLR)4. AMPs stimulate TLR2 in macrophages, increasing the conversion of vitamin D into its active form by cytochrome P450 27B1. Antiviral properties of vitamin D-induced AMPs can shift the polarization of the adaptive immune response from helper T cells (Th)1 to the more regulatory Th2 responses that suppress immune over-reactivity by preventing cytokine storm, which is already demonstrated during the Spanish flu episode.
Vitamin D induces antiviral effects by both direct and indirect mechanisms via

  • AMPs,
  • immunomodulation,
  • the interplay between major cellular and viral elements,
  • induction of autophagy and apoptosis,
  • variation of genetic and epigenetic factors.

The crosstalk between vitamin D and intracellular signaling pathways may operate as a primary regulatory action on viral gene transcription.
VDD may increase the likelihood of infection with enveloped viruses, including

  • retrovirus,
  • hepatitis, and
  • dengue.

Key teaching points
Vitamin D induces antiviral effects by direct and indirect mechanisms via

  • AMPs,
  • immunomodulation,
  • induction of autophagy, etc.

Epidemiology of VDD partly explains geographical differences in COVID-19

  • susceptibility,
  • severity, and
  • mortality.

Global data correlates severe VDD with COVID-19 associated

  • coagulopathy,
  • disrupted immune response and
  • mortality,
  • reduced platelet count, and
  • prolonged prothrombin time,

together suggesting benefits from supplementation. Many clinical trials are underway globally to delineate the role of vitamin D in both prevention and treatment of COVID-19.
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RCT Summary at VitaminDWiki - constantly updated

COVID-19 RCTs


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14262 PT T3.jpg admin 02 Sep, 2020 20:50 611.24 Kb 138
14261 PT T2.jpg admin 02 Sep, 2020 20:49 511.87 Kb 142
14260 Vitamin D in Prevention and Treatment of COVID-19 sci-hub.pdf PDF 2020 admin 02 Sep, 2020 20:46 2.74 Mb 36
14259 PT F2.jpg admin 02 Sep, 2020 20:46 69.09 Kb 140
14258 P T 1.jpg admin 02 Sep, 2020 20:45 202.74 Kb 228
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