Changes in serum 25-hydroxyvitamin D and cholecalciferol after one whole-body exposure in a commercial tanning bed: a randomized study.
Endocrine. 2012 Oct;42(2):430-5. Epub 2012 Mar 6.
Langdahl JH, Schierbeck LL, Bang UC, Jensen JE.
Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark.
We wanted to evaluate the cutaneous synthesis of 25OHD and cholecalciferol after one whole-body exposure to ultraviolet radiation type B (UVB) in a randomized setup. Healthy volunteers were randomized to one whole-body exposure in a commercial tanning bed with UVB emission (UVB/UVA ratio 1.8-2.0%) or an identical placebo tanning bed without UVB. The output in the 280-320 nm range was 450 µW/cm². Blood samples were analyzed for 25OHD and cholecalciferol at baseline and during 7 days after treatment.
We included 20 volunteers, 11 to UVB and 9 to placebo treatment. During the first 6 h, no significant differences in 25OHD between the groups were found. At the end of the study, we found a mean increase of 25OHD in the UVB group of 4.5 nmol/l (SD 7 nmol/l) compared to a decline of -1.2 nmol/l (SD 7 nmol/l) in the placebo group (p = 0.1). A linear mixed model yielded an increase of 25OHD in the UVB group of 1.0 nmol/l per 24 h (p < 0.01). For cholecalciferol, we found a near significant increase of 1 pmol/l per hour in the UVB group compared to the placebo group during the first 6 h (p = 0.052). One tanning bed session had significant, but modest impact on the level of 25OHD during 7 days after exposure to UVB.
Notice: Frequently (but not always) getting just UVA DECREASED the vitamin D levels.
- K. Ukinc, Severe osteomalacia presenting with multiple vertebral fractures: a case report and review of the literature. Endocrine 36, 30–36 (2009) CrossRef
- G. Mazziotti, J. Bilezikian, E. Canalis, D. Cocchi, A. Giustina, New understanding and treatments for osteoporosis. Endocrine 41, 58–69 (2012) CrossRef
- N.C. Bozkurt, E. Cakal, M. Sahin, E.C. Ozkaya, H. Firat, T. Delibasi, The relation of serum 25-hydroxyvitamin-D levels with severity of obstructive sleep apnea and glucose metabolism abnormalities. Endocrine. (2012). doi:10.1007/s12020-012-9595-1
- M. Chung, with or without calcium supplementation for prevention of cancer and fractures: an updated meta-analysis for the U.S. Preventive Services Task Force. Ann. Intern. Med. 155, 827–838 (2011)
- J. McGrath, A. Brown, St CD, Prevention and schizophrenia—the role of dietary factors. Schizophr. Bull. 37, 272–283 (2011) CrossRef
- M.F. Holick, Vitamin D deficiency. N. Engl. J. Med. 357, 266–281 (2007) CrossRef
- M.F. Holick, N.M. Richtand, S.C. McNeill, S.A. Holick, J.E. Frommer, J.W. Henley, J.T. Potts Jr, Isolation and identification of previtamin D3 from the skin of rats exposed to ultraviolet irradiation. Biochemistry 18, 1003–1008 (1979) CrossRef
- M.F. Holick, J.A. MacLaughlin, S.H. Doppelt, Regulation of cutaneous previtamin D3 photosynthesis in man: skin pigment is not an essential regulator. Science 211, 590–593 (1981) CrossRef
- J. MacLaughlin, M.F. Holick, Aging decreases the capacity of human skin to produce vitamin D3. J. Clin. Invest. 76, 1536–1538 (1985) CrossRef
- A.R. Webb, O. Engelsen, Calculated ultraviolet exposure levels for a healthy vitamin D status. Photochem. Photobiol. 82, 1697–1703 (2006)
- A.R. Webb, H. Slaper, P. Koepke, A.W. Schmalwieser, Know your standard: clarifying the CIE erythema action spectrum. Photochem. Photobiol. 87, 483–486 (2011) CrossRef
- H.W. Randle, Suntanning: differences in perceptions throughout history. Mayo Clin. Proc. 72, 461–466 (1997) CrossRef
- J.S. Adams, T.L. Clemens, J.A. Parrish, M.F. Holick, Vitamin-D synthesis and metabolism after ultraviolet irradiation of normal and vitamin-D-deficient subjects. N. Engl. J. Med. 306, 722–725 (1982) CrossRef
- L.A. Armas, S. Dowell, M. Akhter, S. Duthuluru, C. Huerter, B.W. Hollis, R. Lund, R.P. Heaney, Ultraviolet-B radiation increases serum 25-hydroxyvitamin D levels: the effect of UVB dose and skin color. J. Am. Acad. Dermatol. 57, 588–593 (2007) CrossRef
- E. Thieden, H.L. Jorgensen, N.R. Jorgensen, P.A. Philipsen, H.C. Wulf, Sunbed radiation provokes cutaneous vitamin D synthesis in humans—a randomized controlled trial. Photochem. Photobiol. 84, 1487–1492 (2008) CrossRef
- Commission Internationale de l’Eclairage (CIE). Action spectrum for the production of previtamin D3 in human skin. 174 edn. (2006), pp. 1–12
- T.B. Fitzpatrick, The validity and practicality of sun-reactive skin types I through VI. Arch. Dermatol. 124, 869–871 (1988) CrossRef
- B.L. Diffey, C.T. Jansen, F. Urbach, H.C. Wulf, The standard erythema dose: a new photobiological concept. Photodermatol. Photoimmunol. Photomed. 13, 64–66 (1997) CrossRef
- R.D. Ley, L.A. Applegate, R.J. Fry, A.B. Sanchez, Photoreactivation of ultraviolet radiation-induced skin and eye tumors of Monodelphis domestica. Cancer Res. 51, 6539–6542 (1991)
- T.L. Clemens, J.S. Adams, S.L. Henderson, M.F. Holick, Increased skin pigment reduces the capacity of skin to synthesise vitamin D3. Lancet 1, 74–76 (1982) CrossRef
- M.D. Farrar, R. Kift, S.J. Felton, J.L. Berry, M.T. Durkin, D. Allan, A. Vail, A.R. Webb, L.E. Rhodes, Recommended summer sunlight exposure amounts fail to produce sufficient vitamin D status in UK adults of South Asian origin. Am. J. Clin. Nutr. 94, 1219–1224 (2011) CrossRef
- L.Y. Matsuoka, J. Wortsman, J.G. Haddad, P. Kolm, B.W. Hollis, Racial pigmentation and the cutaneous synthesis of vitamin D. Arch. Dermatol. 127, 536–538 (1991) CrossRef
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- All items in category UV and Vitamin D
- Overview UV and vitamin D which has the following
No UVB (Vitamin D) gets thru, but most UVA (Tan) gets thruUVA decreased serum levels of vitamin D - RCT Oct 2012
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- Overview UV and vitamin D which has the following