Nutrients. 2024 Jan 14;16(2):252. doi: 10.3390/nu16020252.
Barbara Owczarek 1 2 3, Anna Ziomkiewicz 4, Edyta Łukowska-Chojnacka 1
'T = tested group, C = Control group, DB = double blind, OL = open label,
RCT = randomized clinical trial, NA = not available,
QE = quasiexperimental, BD = bone density, BP = blood pressure,
COPD = Chronic Obstructive Pulmonary Disease,
VICU = Ventilated Intensive Care Units Patients, RA = rheumatoid arthritis,
CD = cardiovascular disease,
NVF = non- vertebral fractures, MVCIP = Mechanically Ventilated Critically Ill Patients;
** 100,000 IU vitamin D was administered for patients allocated into OL RCT and DB RCT;
Background: Older adults are prone to vitamin D3 (VD3) deficiency, which may impair their health. A high dose of VD3 (HDVD3 = 100,000 IU) could improve their 25-hydroxyvitamin D3 [25(OH)D] level and health outcomes. However, evidence for such a beneficial effect of HDVD3 in older adults coming from clinical trials is mixed.
Objective: To review the literature on the efficacy of a single dose of 100,000 IU of VD3 in older people.
Methods: We searched PubMed/Medline, Science Direct, and NIH's clinical trials registry for clinical studies on the effect of a single high dose of VD3 on various health outcomes in older people. We also performed a meta-analysis using the standardized mean difference to assess the effect of VD3 on its blood level. Due to expected high heterogeneity, its amount (i.e., tau2) was estimated using the DerSimonian-Laird estimator. To estimate tau2, the Q-test for heterogeneity and the I2 statistic were calculated.
Results: Search results identify 13 studies that reported diverse health outcomes, such as lung and cardiovascular function, skin cancer progression, intensive care unit mortality, immune system response, and bone density. The meta-analysis showed a significant increase in 25(OH)D blood levels after treatment in 10 studies, with an average standardized mean difference of 2.60 ng/mL (95% CI: 2.07 to 3.13). Their results suggested that a single high dose of VD3 may benefit intensive care unit patients and skin cancer patients in remission. However, evidence for other beneficial health effects of HDVD3 was mixed due to high heterogeneity among studies.
Conclusions: A single high dose of VD3 may positively affect some health outcomes in older people, possibly due to its pleiotropic and immunomodulatory effects. However, the evidence needs to be more extensive and consistent, and more rigorous studies are required to confirm the benefits and safety of VD3 high doses in older patients.
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29+ VitaminDWiki pages 100 AND 000 AND MONTHLY in the title
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Items found: 29
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Viral infections reduced 40% by monthly 100,000 IU Vitamin D – RCT review Aug 2024 |
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13 Aug, 2024 |
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100,000 IU of Vitamin D monthly (27 ng) is not enough to reduce fractures and falls – meta-analysis April 2024 |
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15 Apr, 2024 |
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100,000 IU of Vitamin D3 monthly for 4 months to diabetics (D2 bombed) – RCT Dec 2019 |
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13 Feb, 2022 |
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Asthma and COPD in a few seniors greatly decreased by monthly 100,000 IU Vitamin D – RCT Feb 2021 |
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28 Jun, 2021 |
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Recurrence of malignant melanoma may be reduced by 100,000 IU of vitamin D monthly – trial underway 2017 |
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13 Mar, 2021 |
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Asthma treated by monthly 100,000 IU of Vitamin D if person had very low levels – RCT Feb 2021 |
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06 Feb, 2021 |
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Smokers helped by Vitamin D (100,000 IU monthly) - RCT Dec 2017 |
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21 Jan, 2021 |
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Vitamin D for infants – 100,000 IU monthly is better than 400 IU daily – RCT Oct 2020 |
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10 Jan, 2021 |
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Diverticular disease:12X reduction if low Vitamin D and given 100,000 IU monthly – RCT Aug 2020 |
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01 Sep, 2020 |
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Monthly 100,000 IU of Vitamin D adds about 25 ng - RCT April 2020 |
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10 Jul, 2020 |
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Vitamin D less costly if give 100,000 IU monthly (but 50,000 IU biweekly should save more money) – July 2019 |
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16 Jul, 2019 |
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Less bone loss if take 100,000 IU vitamin D monthly – RCT Nov 2017 |
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07 Jul, 2019 |
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Fractures reduced by monthly 30,000 IU of Vitamin D, perhaps 100,000 IU would be better – July 2019 |
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07 Jul, 2019 |
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4X reduction in bone fractures following Kidney Transplant with monthly Vitamin D (100,000 IU) - RCT June 2019 |
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17 Jun, 2019 |
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100,000 IU of vitamin D monthly decreases use of NASIDs by 13 percent if low vitamin D – RCT May 2018 |
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25 Dec, 2018 |
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Rheumatoid Arthritis pain reduced by monthly 100,000 IU of Vitamin D – Oct 2018 |
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05 Oct, 2018 |
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Vitamin D RCT using 100,000 IU monthly for a variety of health problems – results of ViDA due in 2016 |
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15 Aug, 2018 |
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Monthly 100,000 IU of vitamin D is safe (and may be better than daily) – RCT Aug 2018 |
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14 Aug, 2018 |
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Pain not relieved by monthly 100,000 IU of vitamin D (need 50,000 IU weekly) – RCT Feb 2018 |
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02 Mar, 2018 |
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Blood pressure reduced by monthly 100,000 IU of vitamin D in those who were deficient – RCT Oct 2017 |
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29 Oct, 2017 |
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Mother got 100,000 IU of vitamin D monthly, breastfeeding infant got a little – RCT Aug 2016 |
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13 Sep, 2017 |
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Why 100,000 IU of vitamin D monthly did not reduce Cardiovascular Disease – RCT April 2017 |
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06 Apr, 2017 |
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Monthly 100,000 IU of vitamin D decreased respiratory infection but increased falls – Nov 2016 |
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10 Dec, 2016 |
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COPD reduced by 40 percent with monthly 100,000 IU of vitamin D – RCT Jan 2015 |
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17 Sep, 2016 |
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Falls cut in half by 100,000 IU vitamin D monthly - RCT 2016 |
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17 Sep, 2016 |
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Monthly 100,000 IU vitamin D supplementation got virtually all vitamin D deficient subjects above 20 ng – RCT April 2014 |
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15 Sep, 2015 |
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2X fewer Senior falls in group getting 100,000 IU vitamin D monthly via Meals-on-Wheels – RCT Aug 2015 |
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18 Aug, 2015 |
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100,000 IU of vitamin D monthly was not enough for 30 percent of the women – Dec 2014 |
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10 Dec, 2014 |
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HIV – recommend 100,000 IU vitamin D monthly to get levels 30 ng – May 2013 |
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18 Oct, 2013 |