Plasma 25-hydroxyvitamin D levels in early-onset severe preeclampsia
American Journal of Obstetrics and Gynecology
doi:10.1016/j.ajog.2010.06.036
Christopher J. Robinson MD, MSCRlow asterisk, Mark C. Alanis MD, MSCRlow asterisk, Carol L. Wagner MD†, Bruce W. Hollis PhD† and Donna D. Johnson MDlow asterisk
† Department of Pediatrics, Medical University of South Carolina, Charleston, SC
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, SC
Received 1 March 2010; revised 8 June 2010; accepted 17 June 2010. Available online 8 August 2010.
OBJECTIVE
Vitamin D deficiency has been linked to adverse pregnancy outcomes. The purpose of this investigation was to assess total 25-hydroxyvitamin D (25-OH-D) levels at diagnosis of early-onset severe preeclampsia (EOSPE).
STUDY DESIGN
After institutional review board approval, we enrolled subjects with EOSPE (<34 weeks' gestation with severe preeclampsia) in this case-control investigation in a 1:2 ratio with gestation-matched, contemporaneous control subjects. Demographic and outcome information was collected for each subject. Plasma total 25-OH-D levels were determined by radioimmunoassay and reported in nanograms per milliliter. Results were analyzed by Mann-Whitney U and multivariable regression.
RESULTS
Subjects with EOSPE (n = 50) were noted to have decreased total 25-OH-D levels relative to healthy control subjects (n = 100; P < .001). This difference in total 25-OH-D remained significant after control for potential confounders.
CONCLUSION
Total 25-OH-D is decreased at diagnosis of EOSPE. Further study is needed to understand the impact of vitamin D deficiency on pregnancy outcomes.