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Infectious diseases and vitamin D – update May 2015

An update on the association of vitamin D deficiency with common infectious diseases.

Can J Physiol Pharmacol. 2015 May;93(5):363-8. doi: 10.1139/cjpp-2014-0352. Epub 2015 Jan 26.
Watkins RR1, Lemonovich TL, Salata RA.
1Department of Internal Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, USA., Division of Infectious Diseases, Akron General Medical Center, Akron, OH 44302, USA.

Vitamin D plays an important role in modulating the immune response to infections. Deficiency of vitamin D is a common condition, affecting both the general population and patients in health care facilities. Over the last decade, an increasing body of evidence has shown an association between vitamin D deficiency and an increased risk for acquiring several infectious diseases, as well as poorer outcomes in vitamin D deficient patients with infections.
This review details recent developments in understanding the role of vitamin D in

  • immunity,
  • the antibacterial actions of vitamin D,
  • the association between vitamin D deficiency and common infections
    (like sepsis, pneumonia, influenza, methicillin-resistant Staphylococcus aureus,
    human immunodeficiency virus type-1 (HIV), and hepatitis C virus (HCV))
  • potential therapeutic implications for vitamin D replacement, and
  • future research directions.

PMID: 25741906
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Cited in Google Scholar by 9 publications as of April 2016


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References by the study

  • Amrein K, Zajic P, Schnedl C, Waltensdorfer A, Fruhwald S, Holl A, et al. 2014. Vitamin D status and its association with season, hospital and sepsis mortality in critical illness. Crit. Care 18(2): R47 CrossRef, Medline.
  • Ansemant T, Mahy S, Piroth C, Ornetti P, Ewing S, Guilland JC, et al. 2013. Severe hypovitaminosis D correlates with increased inflammatory markers in HIV infected patients. BMC Infect. Dis. 13: 7 CrossRef, Medline.
  • Aziz M, Livak B, Burke-Miller J, French AL, Glesby MJ, Sharma A, et al. 2013. Vitamin D insufficiency may impair CD4 recovery among Women’s Interagency HIV Study participants with advanced disease on HAART. AIDS 27(4): 573-578 CrossRef, Medline.
  • Beard JA, Bearden A, Striker R. 2012. Vitamin D and the anti-viral state. J. Clin. Virol. 50(3): 194-200 CrossRef.
  • Bergman P, Lindh AU, Björkhem-Bergman L, Lindh JD. 2013. Vitamin D and respiratory tract infections: a systematic review and meta-analysis of randomized controlled trials. PLoS One 8(6): e65835 CrossRef, Medline.
  • Braun A, Chang D, Mahadevappa K, Gibbons FK, Liu Y, Giovannucci E, et al. 2011. Association of low serum 25-hydroxyvitamin D levels and mortality in the critically ill. Crit. Care Med. 39(4): 671-677 CrossRef, Medline.
  • Campbell GR, Spector SA. 2012. Vitamin D inhibits human immunodeficiency virus type 1 and Mycobacterium tuberculosis infection in macrophages through the induction of autophagy. PLoS Pathog. 8(5): e1002689 CrossRef, Medline.
  • Cervero M, Agud JL, Torres R, García-Lacalle C, Alcázar V, Jusdado JJ, et al. 2013. Higher vitamin D levels in HIV-infected out-patients on treatment with boosted protease inhibitor monotherapy. HIV Med. 14(9): 556-562 CrossRef, Medline.
  • Chen S, Sims GP, Chen XX, Gu YY, Chen S, Lipsky PE. 2007. Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation. J. Immunol. 179(3): 1634-1647 CrossRef, Medline.
  • Coussens AK, Wilkinson RJ, Hanifa Y, Nikolayevskyy V, Elkington PT, Islam K, et al. 2012. Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatment. Proc. Natl. Acad. Sci. U.S.A. 109(38): 15449-15454 CrossRef, Medline.
  • Danai PA, Sinha S, Moss M, Haber MJ, Martin GS. 2007. Seasonal variation in the epidemiology of sepsis. Crit. Care Med. 35(2): 410-415 CrossRef, Medline.
  • Falleti E, Bitetto D, Fabris C, Fattovich G, Cussigh A, Cmet S, et al. 2012. Vitamin D binding protein gene polymorphisms and baseline vitamin D levels as predictors of antiviral response in chronic hepatitis C. Hepatology 56(5): 1641-1650 CrossRef, Medline.
  • Ferreira GB, Kleijwegt FS, Waelkens E, Lage K, Nikolic T, Hansen DA, et al. 2012. Differential protein pathways in 1,25-dihydroxyvitamin D(3) and dexamethasone modulated tolerogenic human dendritic cells. J. Proteome Res. 11(2): 941-971 CrossRef, Medline.
  • Grey A, Bolland M. 2012. Vitamin D and tuberculosis. Proc. Natl. Acad. Sci. U.S.A. 109(51): E3528 CrossRef, Medline.
  • Griffin AT, Arnold FW. 2012. Review of metabolic, immunologic, and virologic consequences of suboptimal vitamin D levels in HIV infection. AIDS Patient Care STDS 26(9): 516-525 CrossRef, Medline.
  • Gunther G. 2014. Multidrug-resistant and extensively drug-resistant tuberculosis: a review of current concepts and future challenges. Clin Med. 14(3): 279-285 CrossRef, Medline.
  • Guzmán-Fulgencio M, García-Álvarez M, Berenguer J, Jiménez-Sousa MÁ, Cosin J, Pineda-Tenor D, et al. 2014. Vitamin D deficiency is associated with severity of liver disease in HIV/HCV coinfected patients. J. Infect. 68(2): 176-184 CrossRef, Medline.
  • Havers F, Smeaton L, Gupte N, Detrick B, Bollinger RC, Hakim J, et al. 2014. 25-Hydroxyvitamin D insufficiency and deficiency is associated with HIV disease progression and virological failure post-antiretroviral therapy initiation in diverse multinational settings. J. Infect. Dis. 210(2): 244-253 CrossRef, Medline.
  • Heine G, Niesner U, Chang HD, Steinmeyer A, Zügel U, Zuberbier T, et al. 2008. 1,25-Dihydroxyvitamin D(3) promotes IL-10 production in human B cells. Eur. J. Immunol. 38(8): 2210-2218 CrossRef, Medline.
  • Hewison M. 2012a. Vitamin D and immune function: an overview. Proc. Nutr. Soc. 71(1): 50-61 CrossRef, Medline.
  • Hewison M. 2012b. An update on vitamin D and human immunity. Clin. Endocrinol. (Oxf.) 76(3): 315-325 CrossRef, Medline.
  • Holick MF. 2007. Vitamin D deficiency. N. Engl. J. Med. 357(3): 266-281 CrossRef, Medline.
  • Honda JR, Connick E, MaWhinney S, Chan ED, Flores SC. 2014. Plasma LL-37 correlates with vitamin D and is reduced in human immunodeficiency virus-1 infected individuals not receiving antiretroviral therapy. J. Med. Microbiol. 63(7): 997-1003 CrossRef, Medline.
  • Iho S, Takahashi T, Kura F, Sugiyama H, Hocino T. 1986. The effect of 1,25-dihydroxyvitamin D3 on in vitro immunoglobulin production in human B cells. J. Immunol. 136(12): 4427-4431 Medline.
  • Jarvis JN, Bicanic T, Loyse A, Meintjes G, Hogan L, Roberts C, et al. 2014. Very low levels of 25-hydroxyvitamin D are not associated with immunologic changes or clinical outcomes in South African patients with HIV-associated cryptococcal meningitis. Clin. Infect. Dis. 59(4): 493-500 CrossRef, Medline.
  • Jefferson T, Jones MA, Doshi P, Del Mar CB, Hama R, Thompson MJ, et al. 2014. Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children. Cochrane Database Syst. Rev. 4: CD008965 CrossRef, Medline.
  • Jeffery LE, Wood AM, Qureshi OS, Hou TZ, Gardner D, Briggs Z, et al. 2012. Availability of 25-hydroxyvitamin D(3) to APCs controls the balance between regulatory and inflammatory T cell responses. J. Immunol. 189(11): 5155-5164 CrossRef, Medline.
  • Jeng L, Yamshchikov AV, Judd SE, Blumberg HM, Martin GS, Ziegler TR, et al. 2009. Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis. J. Transl. Med. 7: 28 CrossRef, Medline.
  • Jorde R, Witham M, Janssens W, Rolighed L, Borchhardt K, de Boer IH, et al. 2012. Vitamin D supplementation did not prevent influenza-like illness as diagnosed retrospectively by questionnaires in subjects participating in randomized controlled trials. Scand. J. Infect. Dis. 44(2): 126-132 CrossRef, Medline.
  • Jovanovich AJ, Ginde AA, Holmen J, Jablonski K, Allyn RL, Kendrick J, et al. 2014. Vitamin D level and risk for community-acquired pneumonia and sepsis. Nutrients 6(6): 2196-2205 CrossRef, Medline.
  • Kim JH, Park JS, Cho YJ, Yoon HI, Song JH, Lee CT, et al. 2014. Low serum 25-hydroxyvitamin D level: An independent risk factor for tuberculosis? Clin. Nutr. 33(6): 1081-1086 CrossRef, Medline.
  • Kitson MT, Dore GJ, George J, Button P, McCaughan GW, Crawford DH, et al. 2013. Vitamin D status does not predict sustained virologic response or fibrosis stage in chronic hepatitis C genotype 1 infection. J. Hepatol. 58(3): 467-472 CrossRef, Medline.
  • Kohchi C, Inagawa H, Nishizawa T, Soma G. 2009. ROS and innate immunity. Anticancer Res. 29(3): 817-822 Medline.
  • Lake JE, Adams JS. 2011. Vitamin D in HIV-Infected Patients. Curr. HIV/AIDS Rep. 8(3): 133-141 CrossRef, Medline.
  • Lange CM, Bojunga J, Ramos-Lopez E, von Wagner M, Hassler A, Vermehren J, et al. 2011. Vitamin D deficiency and a CYP27B1-1260 promoter polymorphism are associated with chronic hepatitis C and poor response to interferon-alfa based therapy. J. Hepatol. 54(5): 887-893 CrossRef, Medline.
  • Leow L, Simpson T, Cursons R, Karalus N, Hancox RJ. 2011. Vitamin D, innate immunity and outcomes in community acquired pneumonia. Respirology 16(4): 611-616 CrossRef, Medline.
  • Levine B, Mizushima N, Virgin HW. 2011. Autophagy in immunity and inflammation. Nature 469(7330): 323-335 CrossRef, Medline.
  • Li-Ng M, Aloia JF, Pollack S, Cunha BA, Mikhail M, Yeh J, Berbari N. 2009. A randomized controlled trial of vitamin D3 supplementation for the prevention of symptomatic upper respiratory tract infections. Epidemiol. Infect. 37(10): 1396-404 CrossRef.
  • Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, et al. 2006. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 311(5768): 1770-1773 CrossRef, Medline.
  • Macaraig M, Burzynski J, Varma JK. 2014. Tuberculosis control in New York City: a changing landscape. N. Engl. J. Med. 370(25): 2362-2365 CrossRef, Medline.
  • Mandorfer M, Payer BA, Schwabl P, Steiner S, Ferlitsch A, Aichelburg MC, et al. 2014. Revisiting liver disease progression in HIV/HCV-coinfected patients: the influence of vitamin D, insulin resistance, immune status, IL28B and PNPLA3. Liver Int. In press CrossRef
  • Marra A, Leoncini G, Mussap M, Bovio M, Nazzari E, Giusti M, et al. 2014. Severe vitamin D deficiency is associated with frequently observed diseases in medical inpatients. Int. J. Clin. Pract. 68(5): 647-652 CrossRef, Medline.
  • Martineau AR, Timms PM, Bothamley GH, Hanifa Y, Islam K, Claxton AP, et al. 2011. High-dose vitamin D(3) during intensive-phase antimicrobial treatment of pulmonary tuberculosis: a double-blind randomised controlled trial. Lancet 377(9761): 242-250 CrossRef, Medline.
  • Matheson EM, Mainous AG III, Hueston WJ, Diaz VA, Everett CJ. 2010. Vitamin D and methicillin-resistant Staphylococcus aureus nasal carriage. Scand. J. Infect. Dis. 42(6–7): 455-460 CrossRef, Medline.
  • Mora JR, Iwata M, von Andrian UH. 2008. Vitamin effects on the immune system: vitamins A and D take centre stage. Nat. Rev. Immunol. 8(9): 685-698 CrossRef, Medline.
  • Moromizato T, Litonjua AA, Braun AB, Gibbons FK, Giovannucci E, Christopher KB. 2014. Association of low serum 25-hydroxyvitamin D levels and sepsis in the critically ill. Crit. Care Med. 42(1): 97-107 CrossRef, Medline.
  • Nguyen HB, Eshete B, Lau KH, Sai A, Villarin M, Baylink D. 2013. Serum 1,25-dihydroxyvitamin D: an outcome prognosticator in human sepsis. PLoS One 8(5): e64348 CrossRef, Medline.
  • Olliver M, Spelmink L, Hiew J, Meyer-Hoffert U, Henriques-Normark B, Bergman P. 2013. Immunomodulatory effects of vitamin D on innate and adaptive immune responses to Streptococcus pneumoniae. J. Infect. Dis. 208(9): 1474-1481 CrossRef, Medline.
  • Ooi JH, McDaniel KL, Weaver V, Cantorna MT. 2014. Murine CD8+ T cells but not macrophages express the vitamin D 1 alpha-hydroxylase. J. Nutr. Biochem. 25(1): 58-65 CrossRef, Medline.
  • Pinzone MR, Di Rosa M, Malaguarnera M, Madeddu G, Focà E, Ceccarelli G, et al. 2013. Vitamin D deficiency in HIV infection: an underestimated and undertreated epidemic. Eur. Rev. Med. Pharmacol. Sci. 17(9): 1218-1232 Medline.
  • Pletz MW, Terkamp C, Schumacher U, Rohde G, Schütte H, Welte T, et al. 2014. Vitamin D deficiency in community-acquired pneumonia: low levels of 1,25(OH)2 D are associated with disease severity. Respir. Res. 15: 53 CrossRef, Medline.
  • Rathored J, Sharma SK, Singh B, Banavaliker JN, Sreenivas V, Srivastava AK, et al. 2012. Risk and outcome of multidrug-resistant tuberculosis: vitamin D receptor polymorphisms and serum 25(OH)D. Int. J. Tuberc. Lung Dis. 16(11): 1522-1528 CrossRef, Medline.
  • Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, et al. 2011. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J. Clin. Endocrinol. Metab. 96(1): 53-58 CrossRef, Medline.
  • Salamon H, Bruiners N, Lakehal K, Shi L, Ravi J, Yamaguchi KD, et al. 2014. Cutting edge: vitamin D regulates lipid metabolism in Mycobacterium tuberculosis infection. J. Immunol. 193(1): 30-34 CrossRef, Medline.
  • Shepherd L, Souberbielle JC, Bastard JP, Fellahi S, Capeau J, Reekie J, et al. 2014. Prognostic value of vitamin D level for all-cause mortality, and association with inflammatory markers, in HIV-infected persons. J. Infect. Dis. 210(2): 234-243 CrossRef, Medline.
  • Shin DM, Yuk JM, Lee HM, Lee SH, Son JW, Harding CV, et al. 2010. Mycobacterial lipoprotein activates autophagy via TLR2/1/CD14 and a functional vitamin D receptor signaling. Cell. Microbiol. 12(11): 1648-1665 CrossRef, Medline.
  • Sundaram ME, Talbot HK, Zhu Y, Griffin MR, Spencer S, Shay DK, et al. 2013. Vitamin D is not associated with serologic response to influenza vaccine in adults over 50 years old. Vaccine 31(16): 2057-2061 CrossRef, Medline.
  • Torres C, Sánchez de la Torre M, García-Moruja C, Carrero AJ, Trujillo Mdel M, Fibla J, et al. 2010. Immunophenotype of vitamin D receptor polymorphism associated to risk of HIV-1 infection and rate of disease progression. Curr. HIV Res. 8(6): 487-492 CrossRef, Medline.
  • Uberti F, Lattuada D, Morsanuto V, Nava U, Bolis G, Vacca G, et al. 2014. Vitamin D protects human endothelial cells from oxidative stress through the autophagic and survival pathways. J. Clin. Endocrinol. Metab. 99(4): 1367-1374 CrossRef, Medline.
  • Vergne I, Chua J, Singh SB, Deretic V. 2004. Cell biology of Mycobacterium tuberculosis phagosome. Annu. Rev. Cell Dev. Biol. 20: 367-394 CrossRef, Medline.
  • Verway M, Bouttier M, Wang TT, Carrier M, Calderon M, An BS, et al. 2013. Vitamin D induces interleukin-1β expression: paracrine macrophage epithelial signaling controls M. tuberculosis infection. PLoS Pathog. 9(6): e1003407 CrossRef, Medline.
  • Villar LM, Del Campo JA, Ranchal I, Lampe E, Romero-Gomez M. 2013. Association between vitamin D and hepatitis C virus infection: a meta-analysis. World J. Gastroenterol. 19(35): 5917-5924 CrossRef, Medline.
  • Wang HE, Shapiro NI, Angus DC, Yealy DM. 2007. National estimates of severe sepsis in the United States emergency departments. Crit. Care Med. 35(8): 1928-1936 CrossRef, Medline.
  • Wang J, Lian H, Zhao Y, Kauss MA, Spindel S. 2008. Vitamin D3 induces autophagy of human myeloid leukemia cells. J. Biol. Chem. 283(37): 25596-25605 CrossRef, Medline.
  • Watkins RR. 2012. Investigating the association between vitamin D deficiency and sepsis: challenges and future prospects. Expert Rev. Anti Infect. Ther. 10(7): 723-725 CrossRef, Medline.
  • Watkins RR, Yamshchikov AV, Lemonovich TL, Salata RA. 2011. The role of vitamin D deficiency in sepsis and potential therapeutic implications. J. Infect. 63(5): 321-326 CrossRef, Medline.
  • Wejse C, Gomes VF, Rabna P, Gustafson P, Aaby P, Lisse IM, et al. 2009. Vitamin D as supplementary treatment for tuberculosis: a double-blind, randomized, placebo-controlled trial. Am. J. Respir. Crit. Care Med. 179(9): 843-850 CrossRef, Medline.
  • Wohl DA, Orkin C, Doroana M, Pilotto JH, Sungkanuparph S, Yeni P, et al. 2014. Change in vitamin D levels and risk of severe vitamin D deficiency over 48 weeks among HIV-1-infected, treatment-naive adults receiving rilpivirine or efavirenz in a Phase III trial (ECHO) Antivir. Ther. 19(2): 191-200 CrossRef, Medline.
  • Xia J, Shi L, Zhao L, Xu F. 2014. Impact of vitamin D supplementation on the outcome of tuberculosis treatment: a systematic review and meta-analysis of randomized controlled trials. Chin. Med. J. (Engl.) 127(17): 3127-3134 Medline.
  • Youssef D, Bailey B, El-Abbassi A, Vannoy M, Manning T, Moorman JP, et al. 2012. Healthcare costs of methicillin resistant Staphylococcus aureus and Pseudomonas aeruginosa infections in veterans: role of vitamin D deficiency. Eur. J. Clin. Microbiol. Infect. Dis. 31(3): 281-286 CrossRef, Medline.

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