Associations Between Concentrations of Vitamin D and Concentrations of Insulin, Glucose, and HbA1c Among Adolescents in the United States.
Diabetes Care. 2011 Jan 27.
Ford ES, Zhao G, Tsai J, Li C.
Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia.
OBJECTIVE Our objective was to examine the associations between concentrations of vitamin D and concentrations of insulin, glucose, and HbA(1c) in a nationally representative sample of adolescents in the U.S.
RESEARCH DESIGN AND METHODS We used data for 1,941 adolescents, aged 12-17 years, who participated in the National Health and Nutrition Examination Survey between 2001 and 2006.
RESULTS Adjusted concentrations of insulin were ~24% lower among male subjects with a concentration of vitamin D ?75 nmol/L than among male subjects with a concentration of vitamin D <50 nmol/L (P = 0.003). Concentrations of vitamin D were inversely associated with concentrations of glucose only among Mexican American male subjects (P = 0.007). No significant associations between concentrations of vitamin D and HbA(1c) were detected.
CONCLUSIONS Our results support an inverse association between concentrations of vitamin D and insulin primarily in adolescent male subjects. PMID: 21273498