Homocysteine, Pyridoxine, Folate and Vitamin B12 Levels in Children with Attention Deficit Hyperactivity Disorder.
Psychiatr Danub. 2018 Sep;30(3):310-316. doi: 10.24869/psyd.2018.310.
Altun H1, Şahin N, Belge Kurutaş E, Güngör O.
Dept. of Child and Adolescent Psychiatry, Faculty of Medicine, Kahramanmaras Sutcu Imam U., Kahramanmaras, Turkey, drhaticealtun at gmail.com.
|ADHD (n=30)||Controls (n=30)||p|
|Vitamin B12 (pg/mL)||260||389||<0.001|
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PDF is available free at Sci-Hub 10.24869/psyd.2018.310
In our study, we aimed to evaluate the serum homocysteine levels, pyridoxine, folate and vitamin B12 levels in children with attention deficit hyperactivity disorders (ADHD).
SUBJECTS AND METHODS:
This study included 30 newly diagnosed drug-naive children with ADHD (23 males and 7 female, mean age 9.3±1.8 years) and 30 sex-and age matched healthy controls. The diagnosis of ADHD was made according to DSM-V criteria. Children and adolescents were administered the Schedule for Affective Disorders and Schizophrenia for School Aged Children, Present and Lifetime Version, the Conners' Parent Rating Scale-Revised, Long Form, the Conners' Teacher Rating Scale and the Wechsler Intelligence Scale for Children Revised (WISC-R) for all participants. Homocysteine, pyridoxine, folate and vitamin B12 levels were measured with enzyme-linked immunosorbent assay.
Homocysteine, pyridoxine, folate and vitamin B12 levels were significantly lower in children with ADHD compared with their controls (p<0.05). A positive significant correlation was observed between the all WISC-R scores and vitamin B12 level in patients (r=0.408, p=0.025).
The results obtained in this study showed that reduced homocysteine, pyridoxine, folate and vitamin B12 levels could be a risk factor in the etiology of ADHD.ADHD associated with significantly less Vitamin B12 – Sept 2018
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