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ADHD associated with low vitamin D in all 8 trials – meta-analysis Oct 2018

Vitamin D levels in children and adolescents with attention-deficit hyperactivity disorder (ADHD): a meta-analysis

ADHD Attention Deficit and Hyperactivity Disorders Journal https://doi.org/10.1007/s12402-018-0276-7
Evangelia Kotsi Elisavet Kotsi Despina N. Perrea

VitaminDWiki

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The aim of this article was to assess the differences in serum 25(OH)D levels between children and adolescents with attention-deficit/hyperactivity disorder (ADHD) and healthy controls. We used the PubMed (1966–2017), Scopus (2004–2017), ClinicalTrials.gov (2008–2017), Cochrane Central Register of Controlled Trials CENTRAL (2000–2017), and Google Scholar (2004–2017) databases. Statistical meta-analysis was performed with RevMan 5.3.
Εight studies were finally included in the present meta-analysis with a total number of 11,324 children. Among them, 2655 were diagnosed with ADHD, while the remaining 8669 were recruited as healthy controls. All eight trials reported significantly lower serum concentrations of 25(OH)D in patients diagnosed with ADHD compared to healthy controls. The pooled data showed that there was a significant difference between the ADHD group and the control group (SMD = − 0.73, 95% CI [− 1.00, − 0.46]). The systematic review and meta-analysis of observational studies demonstrated an inverse association between serum 25(OH)D and young patients with ADHD. Large cohort studies are required to investigate whether vitamin D-deficient infants are more likely to develop ADHD in the future. Also, whether children with ADHD should be supplemented with higher doses of vitamin D3 remains to be confirmed through long-term controlled clinical trials.


Created by admin. Last Modification: Tuesday January 29, 2019 17:48:56 GMT-0000 by admin. (Version 7)

Attached files

ID Name Comment Uploaded Size Downloads
11020 ADHD latitude.jpg admin 08 Dec, 2018 23:04 16.93 Kb 315
11019 ADHD Meta.jpg admin 08 Dec, 2018 23:03 63.03 Kb 331
11018 ADHD Meta.pdf PDF 2018 admin 08 Dec, 2018 23:03 2.45 Mb 284
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