The Efficacy and Safety of High-Dose Cholecalciferol Therapy in Hemodialysis Patients
Biomedicines . 2024 Feb 6;12(2):377. doi: 10.3390/biomedicines12020377.
Agnieszka Tarasewicz 1, Michał Komorniczak 1, Agnieszka Zakrzewska 1, Bogdan Biedunkiewicz 1, Sylwia Małgorzewicz 2, Magdalena Jankowska 1, Katarzyna Jasiulewicz 1, Natalia Płonka 1, Małgorzata Dąbrowska 3, Alicja Dębska-Ślizień 1, Leszek Tylicki 1
Vitamin D deficiency and insufficiency are highly prevalent in CKD, affecting over 80% of hemodialysis (HD) patients and requiring therapeutic intervention. Nephrological societies suggest the administration of cholecalciferol according to the guidelines for the general population. The aim of the observational study was to evaluate the efficacy and safety of the therapy with a high dose of cholecalciferol in HD patients with 25(OH)D deficiency and insufficiency to reach the target serum 25(OH)D level > 30 ng/mL. A total of 22 patients (16 M), with an average age of 72.5 ± 13.03 years and 25(OH)D concentration of 13.05 (9.00-17.90) ng/mL, were administered cholecalciferol at a therapeutic dose of 70,000 IU/week (20,000 IU + 20,000 IU + 30,000 IU, immediately after each dialysis session). All patients achieved the target value > 30 ng/mL, with a mean time of 2.86 ± 1.87 weeks. In the first week, the target level of 25(OH)D (100%) was reached by 2 patients (9.09%), in the second week by 15 patients (68.18%), in the fourth week by 18 patients (81.18%), and in the ninth week by all 22 patients (100%). A significant increase in 1,25(OH)2D levels was observed during the study. However, only 2 patients (9.09%) achieved a concentration of 1,25(OH)2D above 25 ng/mL-the lower limit of the reference range. The intact PTH concentrations remained unchanged during the observation period. No episodes of hypercalcemia were detected, and one new episode of hyperphosphatemia was observed. In conclusion, our study showed that the administration of a high-therapeutic dose of cholecalciferol allowed for a quick, effective, and safe leveling of 25(OH)D concentration in HD patients.
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Vitamin d levels were restored from hemodialysis by 70,000 IU weekly total in 4 weeks - Feb 2024 |
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25 Feb, 2024 |
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Hemodialysis and Vitamin D - many studies |
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20 Jan, 2023 |
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Kidney Dialysis, low Vitamin D, low Magnesium - many studies |
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02 Nov, 2022 |
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Poor cognition 2X more likely in Hemodialysis Patients if low Vitamin D – Sept 2022 |
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20 Sep, 2022 |
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Dialysis patients 23 percent more likely to live if had just 10 ng more Vitamin D – meta-analysis Feb 2018 |
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29 Sep, 2021 |
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Peritoneal dialysis probably consumes a lot more vitamin D than haemodialysis |
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29 Sep, 2021 |
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Hemodialysis associated with very poor mRNA response (wonder if low vitamin D) – March 26, 2021 |
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31 Mar, 2021 |
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2.8X more likely to die of hemodialysis if low on vitamin D |
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26 Mar, 2021 |
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Patients on Hemodialysis 3X more likely if die of heart failure if low Magnesium – meta-analysis Jan 2021 |
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26 Mar, 2021 |
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Vitamin D is needed during Dialysis – initially only 29 pcnt tested, extensive education raised it to 32 pcnt – May 2020 |
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28 Feb, 2021 |
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Kidney Dialysis often filters out Vitamin D, a problem for vegetarians and others- Feb 2021 |
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14 Feb, 2021 |
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Hemodialysis with low vitamin D increases risk of 2 health problems by 10 percent – Aug 2020 |
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06 Aug, 2020 |
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Hemodialysis deaths less likely if take vitamin D, especially if highest dose vitamin D – Nov 2018 |
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10 Nov, 2018 |
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Dialysis patients who added Vitamin D were 41 percent less likely to get infection – Meta-analysis July 2018 |
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31 Jul, 2018 |
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Vitamin D Receptor activators (such as paricalcitol) treat dialysis patients similarly – Aug 2017 |
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27 Aug, 2017 |
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Hemodialysis patients (CKD) helped by weekly 50,000 IU of vitamin D – Jan 2017 |
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27 Jul, 2017 |
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Kidney Dialysis clinics reluctant to add vitamin D treatment as they are not reimbursed – Oct 2012 |
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27 Jul, 2017 |
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Low vitamin D associated with hemodialysis problems – May 2010 |
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13 Mar, 2017 |
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Peritoneal dialysis probably consumes a lot more vitamin D than haemodialysis – April 2014 |
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24 Jun, 2016 |
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Hemodialysis low vitamin D status was normalized with 28500 IU avg daily – Jan 2012 |
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10 Oct, 2015 |
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Hemodialysis not helped by weekly vitamin D2 – RCT April 2015 |
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08 Apr, 2015 |
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Dialysis patients need real vitamin D – Editorial July 2013 |
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08 Apr, 2015 |
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Peritoneal Dialysis nicely treated by active vitamin D – July 2013 |
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04 Feb, 2015 |
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1700 IU of vitamin D not enough to help hemodialysis patients – March 2013 |
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13 Jan, 2015 |
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25,0000 IU vitamin D weekly only raised 60 percent on hemodialysis above 30 ng – Nov 2014 |
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13 Jan, 2015 |
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Application to FDA for use of active Vitamin D for hemodialysis patients – July 2011 |
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18 Feb, 2014 |
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Those Dialysis patients with low vitamin D were 75% more likely to die – July 2013 |
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12 Dec, 2013 |
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Vitamin D3 far better than D2 for hemodialysis – Oct 2012 |
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24 Aug, 2013 |
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Virtually all black dialysis patients with low albumin are vitamin D deficient in the winter – Mar 2010 |
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23 Jul, 2013 |
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Dialysis patients with less than 15 ng of vitamin D did not feel well – March 2011 |
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23 Jul, 2013 |
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Dialysis patients with low vitamin D were 2.7 X more likely to die of heart problems – Feb 2011 |
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23 Jul, 2013 |
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Vitamin D tester falsely said half of hemodialysis patients had less than 30 ng – Jan 2013 |
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01 Jun, 2013 |
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Telomeres longer for dialysis patients having higher levels of vitamin D – March 2012 |
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11 May, 2013 |
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5700 IU of vitamin D helped half with chronic kidney disease if not having dialysis – July 2012 |
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01 Sep, 2012 |
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Majority of blacks on dialysis were vitamin D deficient - March 2010 |
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12 Nov, 2011 |
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Dialysis patients with higher levels of vitamin D were better – May 2011 |
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24 May, 2011 |
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Wearable dialysis device being tested which also converts vitamin D - Mar 2011 |
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04 Mar, 2011 |
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Clinical measures identify vitamin D deficiency in dialysis – Feb 2010 |
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19 Jul, 2010 |
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1700 IU per day of vit D2 was not enough to help dialysis |
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