Major depression associated with vitamin D Binding Protein in youths – March 2018

Bipolar disorder in youth is associated with increased levels of vitamin D-binding protein.

Transl Psychiatry. 2018 Mar 13;8(1):61. doi: 10.1038/s41398-018-0109-7.
Petrov B1, Aldoori A1, James C2, Yang K1,3, Algorta GP4, Lee A1, Zhang L2, Lin T5, Awadhi RA6, Parquette JR5, Samogyi A2, Arnold LE7, Fristad MA7, Gracious B7,8, Ziouzenkova O9.



Intervention of Vitamin D for Depression

Meta-analyses of Vitamin D and Depression

10 most recently added items in Depression category in VitaminDWiki

Id Page Hits Last modification Creator Categories
14434 Infants getting an additional 800 IU of vitamin D for 2 years had 60% fewer psychiatric symptoms at age 7 – RCT May 2023 93
29 May, 2023 22:08
admin Depression
14433 17% of US currently depressed (Vitamin D etc. can reduce it) – May 2023 146
19 May, 2023 17:19
admin Depression
14370 Depression in Icelandic men 2.5 X more likely if vitamin D deficient – Nov 2015 170
10 Apr, 2023 16:06
admin Depression
Vitamin D Far from equator
14357 Perinatal depression decreased pnly by Vitamin D – Meta-analysis April 2023 1788
06 Apr, 2023 12:24
admin Pregnancy
14239 Depression is especially reduced by large intermittent doses of vitamin D – meta-analysis – April 2023 355
19 Mar, 2023 18:24
admin Depression
14235 Depression: Low vitamin D in the strongest of 11 risk factors – Jan 2023 493
28 Jan, 2023 21:06
admin Depression
14197 Depression reduced if take more than 5,000 IU of vitamin D daily – umbrella meta-analysis – Jan 2023 282
07 Jan, 2023 00:03
admin Depression
Meta-analysis of Vitamin D
14166 Anxiety and Depression decreased in senior prediabetics with weekly 25,000 IU of Vitamin D – RCT Sept 2022 223
22 Dec, 2022 02:01
admin Depression
Intervention - non daily
14165 Depression and Anxiety treatment with Vitamin D - probable molecular pathways - June 2022 486
21 Dec, 2022 22:04
admin Depression
14081 Depression decreased by Vitamin D (12th study in VitaminDWiki) – RCT Nov 2022 664
12 Nov, 2022 16:10
admin Depression
Intervention - non daily

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Venn diagram (overlap) of MDD with PTSD, Alcohol Use Disorder and Anxiety


Genetic, dietary, and inflammatory factors contribute to the etiology of major mood disorders (MMD), thus impeding the identification of specific biomarkers to assist in diagnosis and treatment. We tested association of vitamin D and inflammatory markers in 36 adolescents with bipolar disorder (BD) and major depressive disorder (MDD) forms of MMD and without MMD (non-mood control). We also assessed the overall level of inflammation using a cell-based reporter assay for nuclear factor kappa-B (NFκB) activation and measuring antibodies to oxidized LDL. We found that these factors were similar between non-mood and MMD youth. To identify potential biomarkers, we developed a screening immunoprecipitation-sequencing approach based on inflammatory brain glia maturation factor beta (GMFβ). We discovered that a homolog of GMFβ in human plasma is vitamin D-binding protein (DBP) and validated this finding using immunoprecipitation with anti-DBP antibodies and mass spectrometry/sequencing analysis. We quantified DBP levels in participants by western blot. DBP levels in BD participants were significantly higher (136%) than in participants without MMD (100%). The increase in DBP levels in MDD participants (121.1%) was not statistically different from these groups. The DBP responds early to cellular damage by binding of structural proteins and activating inflammatory cells. A product of enzymatic cleavage of DBP has been described as macrophage-activating factor. Circulating DBP is comprised of heterogenous high and low molecular fractions that are only partially recognized by mono- and polyclonal ELISA and are not suitable for the quantitative comparison of DBP in non-mood and MDD participants.
Our data suggest DBP as a marker candidate of BD warranting its validation in a larger cohort of adolescent and adult MMD patients.

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