Database Analysis of Depression and Anxiety in a Community Sample-Response to a Micronutrient Intervention.
Nutrients. 2018 Jan 30;10(2). pii: E152. doi: 10.3390/nu10020152.
Kimball SM1,2, Mirhosseini N3, Rucklidge J4.
- 1 year Canadian trial with 16,000 participants
- Adjusted Vitamin D intake so as to get > 40 ng/ml (measured blood levels)
- All participants also had multi-nutrient pills plus
- Omega-3 fatty acids (400 mg EPA and 200 mg DHA) not appraently measured
- Vitamin C (1000 mg)
- Vitamin B12 (5000 µg methylcobalamin), (measured blood levels)
- Probiotics (Biffidobacterium and Lactobacillus strains, 10 billion CFU)
|Initial Depression Level||% who improved|
Depression category listing has
- Depression reduced by Vitamin D – literature review Feb 2018
- Vitamin D depression RCT canceled: too many were taking Vitamin D supplements, etc. Feb 2018
- Depression greatly reduced by taking 250 mg of Magnesium Chloride daily for 6 weeks– RCT June 2017
Study on this page had only a small amount of Magnesium in the multi-nutrient
- Anti-depression medication about as good as big increase in vitamin D – meta-analysis of flawless data April 2014
- Depression might be reduced by vitamin D – meta-analysis March 2014
- How Omega-3 Fights Depression – LEF July 2016
Study on this page used 400 mg EPA and 200 mg DHA
- REDIT over 1,000 comments within 16 hours
Depression and anxiety are common mental health concerns worldwide. Broad-spectrum multi-vitamin/mineral approaches have been found to alleviate a number of psychiatric symptoms. We investigated the effects of a nutrient intervention program, which includes optimizing vitamin D levels, on depression and anxiety outcomes from community-based program.
We evaluated self-reported health measures of depression and anxiety collected as part of a community-based program focused on optimizing overall health through nutritional supplementation, education and lifestyle advice.
Data were collected from 16,020 participants, with measures including European Quality of Life Five Dimensions (EQ-5D) and Targeted Symptoms List (TSL) providing self-reported depression and anxiety. More than 56% of participants were identified as having elevated levels of depression and anxiety at baseline as reported on the EQ-5D. After one year in the program, 49.2% (n = 7878) of participants who reported any level of depression or anxiety at baseline reported improvement at follow-up. Of those who reported severe/extreme depression at baseline (n = 829), 97.2% reported improvement after one year. Regression analyses revealed a significant association of improvement in depression and anxiety with higher vitamin D status (>100 nmol/L) and more strenuous physical activity.
Overall, people from the general population who suffer from mood and anxiety problems may benefit from improved nutritional status achieved with nutritional supplements.
PMID: 29385721 DOI: 10.3390/nu10020152
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