- Effect of vitamin D supplementation on depression in elderly patients: A randomized clinical trial
11 non-daily Interventions of Vitamin D for Depression - Meta-analyses of Vitamin D and Depression
- Depression category summary
Effect of vitamin D supplementation on depression in elderly patients: A randomized clinical trial
Negin Masoudi Alavia, Saeed Khademalhoseinia,∗, Saeed Khademalhosein Saeed Khademalhoseini, Zarichehr Vakilib, Fatemeh Assarianc
Clinical Nutrition DOI: https://doi.org/10.1016/j.clnu.2018.09.011 |
Background & aims
Treatment of depression in elderly population is a crucial issue. The effect of vitamin D supplementation on treatment of depression in older adults was investigated in this clinical trial.Methods
It was an 8-week, randomized clinical trial of vitamin D supplementation and placebo in the treatment of depression in 3 psychiatric clinics. The study sample included 78 older adults aged over 60 years with moderate to severe depression. Subjects were randomly allocated to receive 50,000 U vitamin D3 pearl weekly for 8 weeks or placebo (39 subjects in each group). Main outcome measures comprised Geriatric Depression Scale-15 (GDS-15) questionnaire and 25-hydroxyvitamin D3 [25(OH)D3]. The analysis utilized Mann Whitney U test, Wilcoxon signed ranks test, chi-square and multiple regression analysis.Results
The mean baseline 25(OH)D3 concentration was 22.57 ± 6.2 ng/ml in vitamin D group and 21.2 ± 5.8 ng/ml in placebo group (p = 0.16). The Vitamin D increased to 43.48 ± 9.5 ng/ml in vitamin D and 25.9 ± 15.3 ng/ml in placebo group. The depression score decreased from 9.25 to 7.48 in vitamin D group (p = 0.0001), while there was a non-significant increase in depression score in placebo group. The multiple regression analysis showed that the vitamin D group and the score of depression before study were the variables that could explain 81.8% of depression score after intervention.Conclusion
The findings indicated that vitamin D supplementation can improve the depression score in persons aged 60 and over.
Download the PDF from Sci-Hub via VitaminDWiki
11 non-daily Interventions of Vitamin D for Depression - Depression is especially reduced by large intermittent doses of vitamin D – meta-analysis – April 2023
- Anxiety and Depression decreased in senior prediabetics with weekly 25,000 IU of Vitamin D – RCT Sept 2022
- Depression decreased by Vitamin D (12th study in VitaminDWiki) – RCT Nov 2022
- Weekly Vitamin D plus daily Magnesium is great (reduced depression in obese women in this case) – July 2021
- Yet another study confirms Depression is treated by weekly Vitamin D (50,000 IU)– RCT Dec 2019
- Depression decreased after vitamin D (50,000 IU weekly to elderly in the case) – RCT Oct 2019
- Vitamin D treatment of diabetes (50,000 IU every 2 weeks) augmented by probiotic – RCT June 2018
- Vitamin D depression RCT canceled: too many were taking Vitamin D supplements, etc. Feb 2018
- Depression in adolescent girls reduced somewhat by 50,000 IU weekly for 9 weeks – July 2017
- 40,000 IU vitamin D weekly reduced depression in many obese subjects – RCT 2008
- 50,000 IU Vitamin D weekly Improves Mood, Lowers Blood Pressure in Type 2 Diabetics – Oct 2013
Many studies have found that Vitamin D taken infrequently is Better than Daily
Meta-analyses of Vitamin D and Depression
- Depression in seniors greatly reduced by Vitamin D (e.g. 50,000 IU) – meta-analysis June 2023
- Depression reduced if take more than 5,000 IU of vitamin D daily – umbrella meta-analysis – Jan 2023
- Depression reduced if use more than 2,800 IU of vitamin D – meta-analysis Aug 2022
- Depression is treated by 2,000 IU of Vitamin D – 2 meta-analyses July 2022
- Depression treated by 50K IU Vitamin D weekly (but not 1,000 IU daily) – meta-analysis Jan 2021
- Mental disorders fought by Omega-3 etc. - meta-meta-analysis Oct 2019
- Depression less likely if more Vitamin D (12 percent per 10 ng) – meta-analysis July 2019
- Anxiety severity reduced if more than 2 grams of Omega-3 – meta-analysis Sept 2018
- Less depression in seniors taking enough Omega-3 – meta-analysis July 2018
- Unipolar depression treated by Omega-3, Zinc, and probably Vitamin D – meta-analysis Oct 2017
- Depression is associated with low Magnesium – meta-analysis April 2015
- Clinical Trials of vitamin D can have “biological flaws” – Jan 2015
- Slight depression not reduced by adding vitamin D if already had enough (no surprise) – meta-analysis – Nov 2014
- Anti-depression medication about as good as big increase in vitamin D – meta-analysis of flawless data April 2014
- Depression might be reduced by vitamin D – meta-analysis March 2014
- Low vitamin D and depression - Study and meta-analysis, April 2013
- 2X more likely to be depressed if low vitamin D (cohort studies) - Meta-analysis Jan 2013
Depression category summary
- Low vitamin D is associated with most types of depression, Including: Seasonal Affective Disorder. manic depression, bipolar disorder, dysthymia, Depression during/after pregnancy, Seniors, Suicide
- Depression substantially reduced by Vitamin D, Omega-3, Magnesium, etc – many studies
- Seasonal Affective Disorder is treated by both bright light and Vitamin D because both make serotonin
- Supplementing with Vitamin D (or getting more sun) decreases most types of depression as well as drugs
- Omega-3, Magnesium, and St. Johns' Wort also decrease depression
- Speculate that some combination (Vit D, Omega-3, Mg, St John's) will decrease depression even more
- Note: Both Omega-3 and Magnesium increase the amount of vitamin D which gets to tissues
- Antidepressants reduce cellular Vitamin D, increasing fractures, CVD, etc. - Oct 2022
- There are
261 items in the Depression category in VitaminDWiki Some recent publications
- Depression in seniors greatly reduced by Vitamin D (e.g. 50,000 IU) – meta-analysis June 2023
- Depression reduced if take more than 5,000 IU of vitamin D daily – umbrella meta-analysis – Jan 2023
- Post-partum depression and low Vitamin D - many studies
- Depression: Low vitamin D in the strongest of 11 risk factors – Jan 2023
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