Vitamin D Receptor BsmI Polymorphism and Osteoporosis Risk: A Meta-Analysis from 26 Studies
Genetic Testing and Molecular Biomarkers – Nov 2012
Rui-Fen Sun,2,* Qun-Hui Li,1 Da-Xing Wang,1 Feng Zhao,1 Jun-Min Li,1 Qi Pu,1 Zhong-Zi Zhang,1 Yan Jin,1 Bai-Lian Liu,1 and Ying Xiong1
1 Department of Orthopedics, Kunming Medical University, National Clinical Key Specialty, Yanan Hospital, Kunming, People's Republic of China.
2 Central Laboratory, Yunnan University of Chinese Traditional Medicine, Kunming, People's Republic of China.
Address correspondence to: Bai-Lian Liu, M.D.; Department of Orthopedics, Kunming Medical University. National Clinical Key Specialty, Yanan Hospital, Kunming, Yunnan 650051
People's Republic of China, E-mail: 1628322036@qq.com
Ying Xiong, M.D.; Department of Orthopedics, Kunming Medical University, National Clinical Key Specialty, Yanan Hospital, Kunming, Yunnan 650051, People's Republic of China. E-mail: xiongying789@126.com
Objective: Growing evidence has shown that vitamin D deficiency can cause lower bone mineral density (BMD) and an increased risk of osteoporosis. Vitamin D receptor (VDR) BsmI polymorphism (rs1544410) can affect BMD variation and circulating osteocalcin levels. To date, a wide range of epidemiological studies have been carried out to evaluate the association between VDR BsmI polymorphism and susceptibility to osteoporosis. Conflicting results, however, were obtained. The aim of this study was to evaluate the effect of VDR BsmI polymorphism on osteoporosis risk using a meta-analysis.
Methods: Twenty-six publications were identified by searching PubMed and Embase databases. The association between VDR BsmI polymorphism and osteoporosis was estimated by calculating pooled odds ratios (ORs) with corresponding 95% confidence intervals (Cis).
Results: The bb genotype was associated with a significantly decreased risk of osteoporosis in overall comparison (
- bb vs. BB: OR=0.61, 95% CI, 0.40–0.92;
- bb vs. BB/Bb: OR=0.70, 95% CI, 0.52–0.95, respectively).
Subgroup analyses showed that the bb genotype had a decreased risk of developing osteoporosis in
- postmenopausal women (bb vs. BB/Bb: OR=0.68, 95% CI, 0.46–0.98) and
- Africans (Bb/bb vs. BB: OR=0.18, 95% CI, 0.09–0.37).
Conclusion: The VDR BsmI polymorphism may have a protective role against the development of osteoporosis.
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PDFs of paper and supplemental data are at bottom of this web page
Forest plot of the meta-analysis (bb vs. BB)
Blacks are particularly affected (supp table 2)
See also VitaminDWiki
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332 items - Search VitaminDWiki for Bsmi 192 items as of Dec 2016
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Vitamin D Receptor category has the following
513 studies in Vitamin D Receptor category Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
See also:
A poor VDR restricts Vitamin D from getting in the cells47 studies in the Resveratrol category It appears that 30% of the population have a poor VDR (40% of the Obese )
Health problems include: Autoimmune (
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
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The Vitamin D Receptor is associated with many health problems19 studies), Breast Cancer ( 22 studies), Colon Cancer ( 13 studies), Cardiovascular ( 23 studies), Cognition ( 16 studies), Diabetes ( 24 studies), Hypertension ( 9 studies), Infant ( 21 studies), Lupus ( 6 studies), Metabolic Syndrome ( 4 studies), Mortality ( 4 studies), Multiple Sclerosis ( 12 studies), Obesity ( 16 studies), Pregnancy ( 24 studies), Rheumatoid Arthritis ( 10 studies), TB ( 8 studies), VIRUS ( 36 studies), Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation
55 health problems associated with poor VDR
A poor VDR is associated with the risk of 55 health problems click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023 click here for details
Some health problem, such as Breast Cancer reduce the VDRVDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
How to increase VDR activation
Compensate for poor VDR by increasing one or more:Increasing Increases 1) Vitamin D supplement Sun
Ultraviolet -BVitamin D in the blood
and thus in the cells2) Magnesium Vitamin D in the blood
AND in the cells3) Omega-3 Vitamin D in the cells 4) Resveratrol Vitamin D Receptor 5) Intense exercise Vitamin D Receptor 6) Get prescription for VDR activator
paricalcitol, maxacalcitol?Vitamin D Receptor 7) Quercetin (flavonoid) Vitamin D Receptor 8) Zinc is in the VDR Vitamin D Receptor 9) Boron Vitamin D Receptor ?,
etc10) Essential oils e.g. ginger, curcumin Vitamin D Receptor 11) Progesterone Vitamin D Receptor 12) Infrequent high concentration Vitamin D
Increases the concentration gradientVitamin D Receptor 13) Sulfroaphane and perhaps sulfur Vitamin D Receptor 14)Butyrate especially gut Vitamin D Receptor Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above
Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR
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