Vitamin D Receptor activators (Resveratrol, Curcumin ,Quercetin) all improve bone – Review Aug 2022


Effects of Resveratrol, Curcumin and Quercetin Supplementation on Bone Metabolism—A Systematic Review

Nutrients 2022, 14(17), 3519; https://doi.org/10.3390/nu14173519
by Alessio Danilo Inchingolo et all

Phenolic compounds are natural phytochemicals that have recently reported numerous health benefits. Resveratrol, curcumin, and quercetin have recently received the most attention among these molecules due to their documented antioxidant effects. The review aims to investigate the effects of these molecules on bone metabolism and their role in several diseases such as osteopenia and osteoporosis, bone tumours, and periodontitis. The PubMed/Medline, Web of Science, Google Scholar, Scopus, Cochrane Library, and Embase electronic databases were searched for papers in line with the study topic. According to an English language restriction, the screening period was from January 2012 to 3 July 2022, with the following Boolean keywords: (“resveratrol” AND “bone”); (“curcumin” AND “bone”); (“quercetin” AND “bone”). A total of 36 papers were identified as relevant to the purpose of our investigation. The studies reported the positive effects of the investigated phenolic compounds on bone metabolism and their potential application as adjuvant treatments for osteoporosis, bone tumours, and periodontitis. Furthermore, their use on the titanium surfaces of orthopaedic prostheses could represent a possible application to improve the osteogenic processes and osseointegration. According to the study findings, resveratrol, curcumin, and quercetin are reported to have a wide variety of beneficial effects as supplement therapies. The investigated phenolic compounds seem to positively mediate bone metabolism and osteoclast-related pathologies.
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VitaminDWiki - 6 studies in both categories VDR and Bone

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VitaminDWiki - Vitamin D Receptor activation can be increased in 14 ways

Resveratrol,  Omega-3,  MagnesiumZinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise, Butyrate   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 14 known VDR activators


VitaminDWiki - The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (19 studies), Breast Cancer (22 studies), Colon Cancer (13 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (24 studies), Hypertension (9 studies), Infant (22 studies), Lupus (6 studies), Metabolic Syndrome (4 studies), Mortality (4 studies), Multiple Sclerosis (12 studies), Obesity (17 studies), Pregnancy (24 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (36 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

VitaminDWiki pages with Vitamin D Receptor or VDR in title (400 as of Oct 2022)

This list is automatically updated

Items found: 437
Title Modified
Which Vitamin D Receptor activator for which health problem - Perplexity AI June 2024 02 Jun, 2024
Lumbar degenerative disc diseases might be fought by Vitamin D Receptor activation– many studies 28 May, 2024
The Vitamin D Receptor is activated by several Traditional Chinese Medicines – Jan 2024 23 May, 2024
Ulcerative Colitis associated with a 90% reduced activation of Vitamin D Receptor – May 2024 16 May, 2024
COVID variants protect themselves by deactivating different VDR variants– March 2023 05 May, 2024
Autoimmune diseases and poor Vitamin D genes – GC, CYP2R1, CYP27B1, and VDR – April 2024 01 May, 2024
Poor sleep was 2X more likely if low Vitamin D and poor Vitamin D receptor – April 2024 08 Apr, 2024
Autism treated by an activator of the Vitamin D Receptor: supforaphane - March 2024 02 Apr, 2024
Lyme disease massively deactivates the Vitamin D Receptor - 2019 31 Mar, 2024
More depression if less vitamin D getting to cells (poor VDR) – March 2024 24 Mar, 2024
COVID death 12X more likely if poor Vitamin D Receptor (less D gets to cells) - many studies 24 Mar, 2024
Hay fever and autism 2X more likely if poor Vitamin D Receptor (children in India) - Jan 2024 15 Mar, 2024
COVID maximum downregulation of Vitamin D receptor and CYP27B1 resulted in death - Feb 2024 14 Mar, 2024
Vitamin D Receptor deactivated by some health problems - many studies 12 Mar, 2024
Diabetes 3X more likely if had COVID ICU (VDR was deactivated) - April 2023 12 Mar, 2024
Colorectal Cancer risk can increase 3X to 30 X, depending on Vitamin D Receptor mutations – Jan 2021 02 Mar, 2024
Vitamin D Receptor (Cancers OR Viruses) - many studies 02 Mar, 2024
Malocclusions 5X higher risk if poor Vitamin D Receptor or low Vitamin D - Feb 2024 14 Feb, 2024
Poor Vitamin D Receptor increases the risk of Multiple Sclerosis in people of European descent – Feb 2024 13 Feb, 2024
Oral Cancer and Vitamin D and VDR - several studies 11 Feb, 2024
Vitamin D Receptor activation in cells varies by 100 X - Carlberg April 2023 10 Feb, 2024
Vitamin D Receptor activation by Traditional Chinese Medicine – Jan 2024 06 Feb, 2024
An activated Vitamin D Receptor fights Autoimmune Diseases, Infections, Cancers, etc. – Dec 2023 13 Jan, 2024
Asthma by age 7 if wheezing before preschools and poor vitamin D Receptor - May 2023 21 Dec, 2023
Berberine: an antioxidant that activates the Vitamin D Receptor - many studies 07 Dec, 2023
Vitamin D Receptor and Obesity – many studies 18 Oct, 2023
Obesity decreases BOTH Vitamin D levels and Vitamin D Receptor activation – Oct 2023 18 Oct, 2023
Vitamin D is associated with 6 genes, 7 receptors, and a new book - Oct 2023 11 Oct, 2023
Sepsis 2X-3X more likely if poor Vitamin D Receptor – meta-analysis Sept 2023 27 Sep, 2023
Microcephaly patients have both poor Vitamin D levels and Receptors - Sept 2023 27 Sep, 2023
Activators of the Vitamin D Receptor include sulforaphane and curcumin – June 2020 19 Sep, 2023
Some essential oils improve health by improving the vitamin D receptor 10 Sep, 2023
Vitamin D Receptors in muscles decrease with age in those with Osteoporosis - 2018 20 Aug, 2023
Dental caries associated with poor Vitamin D receptor – 2016 09 Aug, 2023
Leprosy, low Vitamin D and poor Vitamin D Receptor - many studies 31 Jul, 2023
Infertility risk increased 2.5 X by poor Vitamin D Receptor – July 2023 28 Jul, 2023
DNA and VDR tests - 120 to 200 dollars 28 Jul, 2023
T2 Diabetes might be fought by Vitamin D plus Vitamin D Receptor activators – April 2023 05 Jul, 2023
Autism much more likely if poor Vitamin D Receptor – many studies 25 Jun, 2023
COVID in hospital stopped by Vitamin D Receptor activators (curcumin, quercetin) – RCT June 2023 25 Jun, 2023
Lupus 3.8 X more likely if a poor Vitamin D Receptor – May 2019 07 Jun, 2023
Oral cancers might be prevented and treated by Vitamin D (VDR may be important) – Review May 2023 27 May, 2023
The Vitamin D receptor has been found in 54 human tissues – April 2023 13 May, 2023
Children with COVID 4X more likely to have poor Vitamin D Receptors (Note: COVID deactivates VDR) – April 2023 29 Apr, 2023
Non-Hodgkin’s lymphoma associated with poor Vitamin D receptor – Feb 2021 27 Jan, 2023
Natural activators of the Vitamin D Receptor - some immune cells - April 2023 20 Jan, 2023
Colorectal Cancer 10 percent more likely if poor Vitamin D Receptor – meta-analysis Jan 2023 08 Jan, 2023
Vitamin D Receptor 01 Jan, 2023
Less radiation-induced intestinal injury if activate the Vitamin D receptor (mice) – Dec 2022 29 Dec, 2022
Colon Cancer protects itself by changing the VDR and CYP3A4 genes – Dec 2022 06 Dec, 2022
Gastric Cancer, Vitamin D, VDR, UV - many studies 10 Nov, 2022
Lupus associated with another poor vitamin D gene (CYP27B1 – in addition to low Vitamin D and poor VDR) – Aug 2022 04 Nov, 2022
Breast cancer spreads to bone if poor vitamin D Receptor (no surprise) – Oct 2022 31 Oct, 2022
Vitamin D Receptor activators (Resveratrol, Curcumin ,Quercetin) all improve bone – Review Aug 2022 03 Oct, 2022
COVID kids were more likely to have a poor VDR (4.3 X), than low Vitamin D (2.6 X) – Sept 2022 29 Sep, 2022
A healthy gut needs Vitamin D and a good vitamin D receptor – Sept 2022 20 Sep, 2022
Health problems running in family may be due to poor vitamin D (hypertension, VDR in this case) Sept 2022 06 Sep, 2022
Alzheimer's disease 9X more likely in females with a poor Vitamin D Receptor – Sept 2022 27 Aug, 2022
Fibromyalgia Syndrome correlated with poor Vitamin D Receptor (less D to cells) in a small study – July 2022 24 Aug, 2022
Cancers are associated with low vitamin D, poor vaccination response and perhaps poor VDR – July 2022 15 Aug, 2022
Alzheimer's 9X more likely in women with a poor Vitamin D receptor – Sept 2022 11 Aug, 2022
Vitamin D Receptors are both inside the cell and at the cell membrane – July 2020 09 Aug, 2022
CBD may be synergistic with Vitamin D (improves VDR in rats) - Aug 2022 08 Aug, 2022
Cardiovascular disease 2.3 X more-likely if poor Vitamin D Receptor – Aug 2022 04 Aug, 2022
PFAS (forever chemicals) reduce Vitamin D and VDR, cause health problems - many studies 29 Jul, 2022
Some breast cancers may prevented by VDR – March 2022 27 Jul, 2022
Poor prognosis of solid childhood cancers 14.7 X more likely with a poor Vitamin D Receptor – July 2022 27 Jul, 2022
COVID 3X more likely if a poor Receptor (cells get less Vitamin D from the blood) – July 2022 21 Jul, 2022
2X increase risk of Asthma if a particular Vitamin D Receptor mutation – meta-analysis Feb 2022 04 Jul, 2022
14th activator of the Vitamin D Receptor – Butyrate (from gut bacteria, or supplement) 01 Jul, 2022
Poor oral bacteria associated with poor Vitamin D Receptor - June 2022 24 Jun, 2022
Parkinson’s Disease 3 X more likely if a poor Vitamin D Receptor – May – 2022 06 May, 2022
Genes that increase the risk of Osteoporosis: Vitamin D Receptor is number one in Asians– April 2022 23 Apr, 2022
Alzheimer's disease 1.8 X higher risk if poor Vitamin D Receptor (if not take action) - May 2022 11 Apr, 2022
Periodontitis problems often 3X more likely if poor Vitamin D receptor – May 2022 07 Apr, 2022
BPH increased risk if poor Vitamin D Receptor in Asians – meta-analysis April 2022 06 Apr, 2022
Vitamin D up and down regulates 1,000’s of genes via the Vitamin D Receptor – March 2022 24 Mar, 2022
Parkinson’s Disease might be fought by Vitamin D and the activation of the Vitamin D Receptor – March 2022 14 Mar, 2022
Parkinson's Disease associations with Vitamin D Receptor and GC gene – June 2016 14 Mar, 2022
Poor Vitamin D receptor reduced vitamin D levels -meta-analysis Jan 2022 23 Jan, 2022
The Vitamin D Receptor is associated with many health problems 26 Dec, 2021
Intense exercise increases vitamin D receptor activation 26 Dec, 2021
COVID severity, ICU, and mortality all associated with poor vitamin D receptor (but not D, everyone had low D) -Dec 2021 25 Dec, 2021
Different Vitamin D Receptor problems cause different COVID problems - Dec 2021 18 Dec, 2021
Gestational Diabetes – increased risk if poor Vitamin D Receptor – 2 Meta-Analyses 2021 14 Dec, 2021
COVID, influenza, hepatitis B, measles, etc. vaccine responses vary with Vitamin D and its receptor 08 Dec, 2021
Gout 1.5 X more likely if a poor Vitamin D Receptor – 2014 04 Nov, 2021
Cancers and Vitamin D Receptors, including change with race – Feb 2021 24 Oct, 2021
Needing a high level of vitamin D is a good clue that the Vitamin D Receptor is deactivated 18 Oct, 2021
Breast Cancer reduces receptor and thus blocks Vitamin D to the cells – several studies 18 Oct, 2021
Poor Vitamin D receptor blocked Vitamin D from fighting avian influenza viruses (in mice) – July 2021 17 Oct, 2021
Epstein-Barr is yet another virus that deactivates the Vitamin D receptor (COVID later suspected as well)– 2010 17 Oct, 2021
COVID-19 symptoms and comorbidities associated with the type of Vitamin D Receptor – Oct 2021 09 Oct, 2021
Autism 2X to 3X more likely if poor Vitamin D Receptor – June 2020 09 Oct, 2021
Little Vitamin D benefit if poor Vitamin D Receptor (400 studies annually) - Oct 2021 05 Oct, 2021
Enveloped virus infection (RSV, coronavirus, HIV, etc.) 1.5X more likely if poor Vitamin D Receptor – meta-analysis Dec 2018 02 Oct, 2021
PMS fatigue 2.5X more likely if poor vitamin D Receptor – Sept 2021 23 Sep, 2021
Skin scars (Keloids) more likely if low vitamin D, poor Vitamin D receptor, or dark skin – Aug 2021 13 Sep, 2021
Poor Receptor predicts sepsis death (restricts Vitamin D from getting to cells) – Aug 2021 16 Aug, 2021
The vitamin d receptor and T cell function- June 2013 05 Aug, 2021
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